Clinical Utility of Pro-inflammatory Oligomeric Glycoprotein Tenascin-C in the Diagnosis of Seropositive and Seronegative Rheumatoid Arthritis

Owing to limited usefulness of Rheumatoid Factor and anti-CCP in rheumatoid arthritis, there is a need to identify a more sensitive and specific biomarker to detect rheumatoid arthritis (RA), particularly seronegative RA cases. Tenascin-C is an extracellular matrix glycoprotein, which has been impli...

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Published in:Indian journal of clinical biochemistry 2024-01, Vol.39 (1), p.110-117
Main Authors: Dominic, Sachin, Baba, K. S. S. Sai, Sreedevi, N. N., Sanober, Arshi, Rajasekhar, Liza, Khan, Siraj Ahmed, Mohammed, Noorjahan, Bhaskar, M. Vijaya, Mohan, Iyyapu Krishna
Format: Article
Language:English
Subjects:
Arthritis
Biochemistry
Biomedical and Life Sciences
Chemistry/Food Science
Enzyme immunoassay
Extracellular matrix
Glycoproteins
Inflammation
Life Sciences
Medical research
Medicine, Experimental
Microbiology
Original
Original Research Article
Pathology
Rheumatoid arthritis
Rheumatoid factor
Tenascin
Tenascin C
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Summary:Owing to limited usefulness of Rheumatoid Factor and anti-CCP in rheumatoid arthritis, there is a need to identify a more sensitive and specific biomarker to detect rheumatoid arthritis (RA), particularly seronegative RA cases. Tenascin-C is an extracellular matrix glycoprotein, which has been implicated in the pathophysiology of RA. The objective of our study was to evaluate the diagnostic utility of serum Tenascin-C in seropositive and seronegative rheumatoid arthritis patients. We conducted a cross-sectional case control study. Sixty patients who fulfilled the ACR 2010 criteria for rheumatoid arthritis were included in the study. Thirty patients were found to be positive for RF and/or anti-CCP and 30 were negative for both RF and anti-CCP. Thirty age and gender-matched healthy subjects were taken as controls. Serum Tenascin-C was measured by quantitative sandwich enzyme immunoassay technique. The mean serum concentration of Tenascin-C in controls, seronegative and seropositive cases was 0.66 ng/ml, 20.54 ng/ml and 23.42 ng/ml, respectively. Tenascin-C levels were significantly higher in RA cases compared to controls ( p  
ISSN:0970-1915
0974-0422
DOI:10.1007/s12291-022-01086-0