A History of Suicide Attempt Is Associated with Increased Sympathetic Activation in Bipolar Disorder

Suicide risk in bipolar disorder (BD) is estimated to be up to 20 times higher than in the general population. While there is a large body of evidence suggesting that increased sympathetic activation is associated with disease and death, there is a paucity of research on the role of autonomic nervou...

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Bibliographic Details
Published in:Canadian journal of psychiatry 2024-02, Vol.69 (2), p.126-137
Main Authors: Ortiz, Abigail, Park, Yunkyung, MacLean, Stephane, Husain, M Ishrat, Sanches, Marcos, Ravindran, Arun, Mulsant, Benoit H
Format: Article
Language:English
Subjects:
Bipolar disorder
Bipolar Disorder - epidemiology
Cost of Illness
Heart rate
Humans
Original Research
Risk Factors
Suicidal behavior
Suicidal Ideation
Suicide, Attempted
Suicides & suicide attempts
Violence
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Summary:Suicide risk in bipolar disorder (BD) is estimated to be up to 20 times higher than in the general population. While there is a large body of evidence suggesting that increased sympathetic activation is associated with disease and death, there is a paucity of research on the role of autonomic nervous system (ANS) dysfunction in patients with BD who have attempted suicide. Fifty-three participants with BD used a wearable device to assess the association between history of suicide attempt, current suicidal ideation, and ANS dysfunction, including measures of heart rate variability (HRV) and respiratory rate. Data were analyzed in a series of unadjusted and adjusted bivariate models of association controlling for relevant variables. A history of suicide attempts was significantly associated with an increase in respiratory rate (  
ISSN:0706-7437
1497-0015
1497-0015
DOI:10.1177/07067437231194334