The Lack of Alterations in Metabolites in the Medial Prefrontal Cortex and Amygdala, but Their Associations with Autistic Traits, Empathy, and Personality Traits in Adults with Autism Spectrum Disorder: A Preliminary Study

Proton magnetic resonance spectroscopy ( 1 H-MRS) has shown inconsistent alterations in brain metabolites of adults with autism spectrum disorder (ASD). We investigated brain metabolites in the medial prefrontal cortex and amygdala of 24 drug-naive adults with ASD and no intellectual disability and...

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Bibliographic Details
Published in:Journal of autism and developmental disorders 2024-01, Vol.54 (1), p.193-210
Main Authors: Shirayama, Yukihiko, Matsumoto, Kazuki, Osone, Fumio, Hara, Akira, Guan, Siqing, Hamatani, Sayo, Muneoka, Katsumasa, Sato, Koichi, Okada, Akihiro, Yokokawa, Tokuzou
Format: Article
Language:English
Subjects:
Adults
Affect (Psychology)
Amygdala
Autism
Autistic adults
Behavioral Science and Psychology
Brain
Child and School Psychology
Cognitive ability
Complications and side effects
Cortex
Creatine
Diagnosis
Emotions
Empathy
Evaluation
Health aspects
Initiatives
Inositol
Intellectual disabilities
Magnetic resonance spectroscopy
Metabolites
N-Acetylaspartate
Neo Personality Inventory
Neurosciences
Original Paper
Pediatrics
Personality
Personality traits
Pervasive developmental disorders
Phosphocreatine
Phosphorylcholine
Prefrontal cortex
Psychological aspects
Psychology
Public Health
Questionnaires
Reactivity
Research subjects
Spectrum analysis
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Summary:Proton magnetic resonance spectroscopy ( 1 H-MRS) has shown inconsistent alterations in brain metabolites of adults with autism spectrum disorder (ASD). We investigated brain metabolites in the medial prefrontal cortex and amygdala of 24 drug-naive adults with ASD and no intellectual disability and 24 non-ASD control subjects, using 3 T 1 H-MRS. Adults with ASD showed no significant differences from control in glutamate, glutamate plus glutamine, N-acetylaspartate, glycerophosphorylcholine plus phosphorylcholine, creatine plus phosphocreatine, or myo-inositol in either region. However, ASD subjects did show significant correlations of localized brain metabolites with autistic traits, empathy deficits, and personality traits using the Autism-Spectrum Quotient, Questionnaire of Cognitive and Affective Empathy, Interpersonal Reactivity Index, and NEO Personality Inventory-Revised. These findings should be taken as preliminary or exploratory.
ISSN:0162-3257
1573-3432
DOI:10.1007/s10803-022-05778-7