Comparison of Clostridioides difficile nucleic acid amplification test (NAAT) results using fresh and frozen stool specimens and rectal swabs

Nucleic acid amplification tests (NAATs) are frequently used in research and diagnostic testing, but the effect of freezing specimens on NAAT performance is not well characterized. This study evaluated the concordance of NAAT results between fresh and frozen specimens (fecal and rectal swabs) and fo...

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Bibliographic Details
Published in:Journal of clinical microbiology 2024-01, Vol.62 (1), p.e0103723-e0103723
Main Authors: Dumm, Rebekah E, Burnham, Carey-Ann D, Hink, Tiffany, Reske, Kimberly A, Struttmann, Emily, Iqbal, Zainab Hassan, Cass, Candice, Kwon, Jennie H, Olsen, Margaret A, Dubberke, Erik R
Format: Article
Language:English
Subjects:
Bacteriology
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Summary:Nucleic acid amplification tests (NAATs) are frequently used in research and diagnostic testing, but the effect of freezing specimens on NAAT performance is not well characterized. This study evaluated the concordance of NAAT results between fresh and frozen specimens (fecal and rectal swabs) and found it to be very good to excellent. The results indicate that frozen fecal and rectal swab specimens may be used for NAAT testing in research when fresh specimens are not available.
ISSN:0095-1137
1098-660X
DOI:10.1128/jcm.01037-23