Doctors’ Confusion over Ratios and Percentages in Drug Solutions: The Case for Standard Labelling

• Published in: Journal of the Royal Society of Medicine 2004-08, Vol.97 (8), p.380-383
• Main Authors: Wheeler, Daniel Wren, Remoundos, Dionysios Dennis, Whittlestone, Kim David, Palmer, Michael Ian, Wheeler, Sarah Jane, Ringrose, Timothy Richard, Menon, David Krishna
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Clinical Competence - standards; Drug Labeling - standards; General aspects; Humans; Medical sciences; Medicine; Original; Pharmaceutical Solutions - standards; Physicians - standards; Specialization; Surveys and Questionnaires; United Kingdom
• ISSN: 0141-0768; 1758-1095
• DOI: 10.1177/014107680409700805

The different ways of expressing concentrations of drugs in solution, as ratios or percentages or mass per unit volume, are a potential cause of confusion that may contribute to dose errors. To assess doctors’ understanding of what they signify, all active subscribers to doctors.net.uk, an online community exclusively for UK doctors, were invited to complete a brief web-based multiple-choice questionnaire that explored their familiarity with solutions of adrenaline (expressed as a ratio), lidocaine (expressed as a percentage) and atropine (expressed in mg per mL), and their ability to calculate the correct volume to administer in clinical scenarios relevant to all specialties. 2974 (24.6%) replied. The mean score achieved was 4.80 out of 6 (SD 1.38). Only 85.2% and 65.8% correctly identified the mass of drug in the adrenaline and lidocaine solutions, respectively, whilst 93.1% identified the correct concentration of atropine. More would have administered the correct volume of adrenaline and lidocaine in clinical scenarios (89.4% and 81.0%, respectively) but only 65.5% identified the correct volume of atropine. The labelling of drug solutions as ratios or percentages is antiquated and confusing. Labelling should be standardized to mass per unit volume.