An Update on Anti-Vascular Endothelial Growth Factor Treatment for Retinopathy of Prematurity

To present updated information on the role of anti-vascular endothelial growth factor (anti-VEGF) therapy for treating retinopathy of prematurity (ROP). We searched through PubMed and Scopus databases using the keywords of this article and gathered relevant published articles from the year 2005 to D...

Full description

Saved in:
Bibliographic Details
Published in:Iranian journal of ophthalmology 2023-04, Vol.35 (2), p.125-134
Main Authors: Nowroozzadeh, M Hossein, Sadeghi, Elham, Shahriari-Garaee, Hossein, Badie, Mohammad Reza, Banihashemi, Javad, Garg, Sunir J
Format: Article
Language:English
Subjects:
Review
Vascular endothelial growth factor
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To present updated information on the role of anti-vascular endothelial growth factor (anti-VEGF) therapy for treating retinopathy of prematurity (ROP). We searched through PubMed and Scopus databases using the keywords of this article and gathered relevant published articles from the year 2005 to December 2022. The selected articles were classified and summarized, and reasonable conclusions were made accordingly. Considering the current evidence, anti-VEGF agents are superior to laser therapy for the initial treatment of type 1 ROP in zone 1 or posterior zone 2. However, there is a substantial risk of reactivation or persistent avascular retina after solo treatment with anti-VEGFs, and many cases may require laser therapy within the following weeks or months. Thus, vigilant follow-up examinations are mandatory. The role of anti-VEGF agents in the treatment of ROP is indispensable. However, future studies are required to improve indications and dosage and determine long-term ocular and systemic safety.
ISSN:2452-2325
2452-2325
DOI:10.4103/joco.joco_38_23