Oxygen-sensing pathways below autoregulatory threshold act to sustain myocardial oxygen delivery during reductions in perfusion pressure

The coronary circulation has an innate ability to maintain constant blood flow over a wide range of perfusion pressures. However, the mechanisms responsible for coronary autoregulation remain a fundamental and highly contested question. This study interrogated the local metabolic hypothesis of autor...

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Bibliographic Details
Published in:Basic research in cardiology 2023-03, Vol.118 (1), p.12-12, Article 12
Main Authors: Warne, Cooper M., Essajee, Salman I., Tucker, Selina M., Figueroa, C. Alberto, Beard, Daniel A., Dick, Gregory M., Tune, Johnathan D.
Format: Article
Language:English
Subjects:
Animals
Blood circulation
Blood flow
Blood Pressure
Cardiology
Coronary circulation
Coronary Circulation - physiology
Dobutamine - pharmacology
Error signals
Homeostasis - physiology
Hypotheses
Hypoxemia
Hypoxia
Medicine
Medicine & Public Health
Metabolism
Myocardium - metabolism
Original Contribution
Oxygen
Oxygen consumption
Oxygen Consumption - physiology
Oxygen content
Perfusion
Swine
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Summary:The coronary circulation has an innate ability to maintain constant blood flow over a wide range of perfusion pressures. However, the mechanisms responsible for coronary autoregulation remain a fundamental and highly contested question. This study interrogated the local metabolic hypothesis of autoregulation by testing the hypothesis that hypoxemia-induced exaggeration of the metabolic error signal improves the autoregulatory response. Experiments were performed on open-chest anesthetized swine during stepwise changes in coronary perfusion pressure (CPP) from 140 to 40 mmHg under normoxic (n = 15) and hypoxemic (n = 8) conditions, in the absence and presence of dobutamine-induced increases in myocardial oxygen consumption (MVO 2 ) (n = 5–7). Hypoxemia (PaO 2  
ISSN:1435-1803
0300-8428
1435-1803
DOI:10.1007/s00395-023-00985-4