Coordination of anti-CTLA-4 with whole-brain radiation therapy decreases tumor burden during treatment in a novel syngeneic model of lung cancer brain metastasis

Lung cancer is the most common primary tumor to metastasize to the brain. Although advances in lung cancer therapy have increased rates of survival over the past few decades, control and treatment of lung cancer brain metastasis remains an urgent clinical need. Herein, we examine the temporal coordi...

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Bibliographic Details
Published in:Cancer Immunology, Immunotherapy Immunotherapy, 2024-01, Vol.73 (1), p.20, Article 20
Main Authors: Blethen, K. E., Wolford, C. P., Pecar, G. L., Arsiwala, T. A., Adjeroh, E., Dykstra, L. P., Kielkowski, B. N., Lockman, P. R.
Format: Article
Language:English
Subjects:
Animals
Brain
Brain cancer
Brain Neoplasms - radiotherapy
Brain Neoplasms - secondary
Brain tumors
Cancer Research
Cancer therapies
Cranial Irradiation
CTLA-4 Antigen
CTLA-4 protein
Immunology
Immunotherapy
Immunotherapy - methods
Lung cancer
Lung Neoplasms - pathology
Lung Neoplasms - radiotherapy
Medicine
Medicine & Public Health
Metastases
Metastasis
Mice
Mice, Nude
Neoplasm Recurrence, Local
Oncology
Radiation therapy
Survival
Tumor Burden
Weight Loss
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Summary:Lung cancer is the most common primary tumor to metastasize to the brain. Although advances in lung cancer therapy have increased rates of survival over the past few decades, control and treatment of lung cancer brain metastasis remains an urgent clinical need. Herein, we examine the temporal coordination of α-CTLA-4 administration in combination with whole-brain radiation therapy in a syngeneic preclinical model of lung cancer brain metastasis in both C57Bl/6 and athymic nude mice. Brain tumor burden, survival, and weight loss were monitored. Immunotherapy administration 24 h prior to irradiation resulted in increased brain tumor burden, while administration of immunotherapy 12 h after radiation decreased tumor burden. Neither of the treatments affected survival outcomes or weight loss due to brain tumor recurrence. These findings suggest that the coordination of α-CTLA-4 administration in addition to whole-brain radiation therapy may be a viable strategy for reduction of tumor burden for the management of lung cancer brain metastasis.
ISSN:0340-7004
1432-0851
1432-0851
DOI:10.1007/s00262-023-03599-w