Surface fibrils on the particles of nucleocytoviruses: A review

• Published in: Experimental Biology and Medicine 2023-11, Vol.248 (22), p.2045-2052
• Main Authors: Aquino, Isabella Luiza Martins de, Barcelos, Matheus Gomes, Machado, Talita Bastos, Serafim, Mateus Sá Magalhães, Abrahão, Jônatas Santos
• Format: Article
• Language: English
• Subjects: Capsid - chemistry; Capsid - metabolism; Capsid Proteins - analysis; Capsid Proteins - genetics; Capsid Proteins - metabolism; Giant Viruses - genetics; Mimiviridae - genetics; Minireview; Viruses
• ISSN: 1535-3702; 1535-3699
• DOI: 10.1177/15353702231208410

The capsid has a central role in viruses’ life cycle. Although one of its major functions is to protect the viral genome, the capsid may be composed of elements that, at some point, promote interaction with host cells and trigger infection. Considering the scenario of multiple origins of viruses along the viral evolution, a substantial number of capsid shapes, sizes, and symmetries have been described. In this context, capsids of giant viruses (GV) that infect protists have drawn the attention of the scientific community, especially in the last 20 years, specifically for having bacterial-like dimensions with hundreds of different proteins and exclusive features. For instance, the surface fibrils present on the mimivirus capsid are one of the most intriguing features of the known virosphere. They are 150-nm-long structures attached to a 450-nm capsid, resulting in a particle with a hairy appearance. Surface fibrils have also been described in the capsids of other nucleocytoviruses, although they may differ substantially among them. In this mini review for non-experts, we compile the most important available information on surface fibrils of nucleocytoviruses, discussing their putative functions, composition, length, organization, and origins.