New diagnostic criteria (2023) for slowly progressive type 1 diabetes (SPIDDM): Report from Committee on Type 1 Diabetes in Japan Diabetes Society (English version)

• Published in: Diabetology international 2024-01, Vol.15 (1), p.1-4
• Main Authors: Shimada, Akira, Kawasaki, Eiji, Abiru, Norio, Awata, Takuya, Oikawa, Yoichi, Osawa, Haruhiko, Kajio, Hiroshi, Kozawa, Junji, Takahashi, Kazuma, Chujo, Daisuke, Noso, Shinsuke, Fukui, Tomoyasu, Miura, Junnosuke, Yasuda, Kazuki, Yasuda, Hisafumi, Imagawa, Akihisa, Ikegami, Hiroshi
• Format: Article
• Language: English
• Subjects: Autoantibodies; Diabetes; Diabetes mellitus (insulin dependent); Diabetes mellitus (non-insulin dependent); Diagnosis; Endocrinology; Hyperglycemia; Immunoreactivity; Insulin secretion; Ketoacidosis; Medical diagnosis; Medicine; Medicine & Public Health; Metabolic Diseases; Report of the Committee
• ISSN: 2190-1678; 2190-1686
• DOI: 10.1007/s13340-023-00679-1

The diagnostic criteria for slowly progressive type 1 diabetes (slowly progressive insulin-dependent diabetes mellitus; SPIDDM) have been revised by the Committee on Type 1 Diabetes of the Japan Diabetes Society. All of the following three criteria must be met for “a definitive diagnosis of SPIDDM”: (1) presence of anti-islet autoantibodies at some point in time during the disease course; (2) absence of ketosis or ketoacidosis at the diagnosis of diabetes with no requirement of insulin treatment to correct hyperglycemia immediately after diagnosis in principle; and (3) gradual decrease of insulin secretion over time, with insulin treatment required at more than 3 months after diagnosis, and presence of severe endogenous insulin deficiency (fasting serum C-peptide immunoreactivity