Cholesterol associated genetic risk score and acute coronary syndrome in Czech males

Background Despite a general decline in mean levels across populations, LDL-cholesterol levels remain a major risk factor for acute coronary syndrome (ACS). The APOB , LDL-R , CILP , and SORT-1 genes have been shown to contain variants that have significant effects on plasma cholesterol levels. Meth...

Full description

Saved in:
Bibliographic Details
Published in:Molecular biology reports 2024-12, Vol.51 (1), p.164, Article 164
Main Authors: Hubacek, Jaroslav A., Adamkova, Vera, Lanska, Vera, Staněk, Vladimir, Mrázková, Jolana, Gebauerová, Marie, Kettner, Jiri, Kautzner, Josef, Pitha, Jan
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - genetics
Acute coronary syndromes
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Cholesterol
Czech Republic - epidemiology
Genetic Risk Score
Histology
Humans
Life Sciences
Low density lipoprotein
Male
Morphology
Mortality
Original
Original Article
Polymorphism, Single Nucleotide - genetics
Risk factors
Single-nucleotide polymorphism
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Despite a general decline in mean levels across populations, LDL-cholesterol levels remain a major risk factor for acute coronary syndrome (ACS). The APOB , LDL-R , CILP , and SORT-1 genes have been shown to contain variants that have significant effects on plasma cholesterol levels. Methods and results We examined polymorphisms within these genes in 1191 controls and 929 patients with ACS. Only rs646776 within SORT-1 was significantly associated with a risk of ACS (P 
ISSN:0301-4851
1573-4978
1573-4978
DOI:10.1007/s11033-023-09128-3