Intra-serotypic antigenic diversity of dengue virus serotype 3 in Thailand during 2004–2015

In addition to the well-known differences among the four dengue serotypes, intra-serotypic antigenic diversity has been proposed to play a role in viral evolution and epidemic fluctuation. A replacement of genotype II by genotype III of dengue virus serotype 3 (DENV3) occurred in Thailand during 200...

Full description

Saved in:
Bibliographic Details
Published in:Epidemiology and infection 2024-01, Vol.152, p.e11
Main Authors: Masrinoul, Promsin, Sun-Arlee, Panumas, Yoksan, Sutee, Wanlayaporn, Duangnapa, Juntarapornchai, Sanjira, Punyahathaikul, Surat, Ketsuwan, Kunjimas, Palabodeewat, Somnuek, Kongchanagul, Alita, Auewarakul, Prasert
Format: Article
Language:English
Subjects:
Amino acids
Antibodies
Antigenic Variation
Antigens
Dengue - epidemiology
Dengue fever
Dengue Virus - genetics
Genotype & phenotype
Genotypes
Humans
Infections
Laboratories
Neutralization
Original Paper
Phylogenetics
Ribonucleic acid
RNA
Serogroup
Serotypes
Software
Subgroups
Thailand - epidemiology
Vaccine efficacy
Vaccines
Vector-borne diseases
Viruses
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In addition to the well-known differences among the four dengue serotypes, intra-serotypic antigenic diversity has been proposed to play a role in viral evolution and epidemic fluctuation. A replacement of genotype II by genotype III of dengue virus serotype 3 (DENV3) occurred in Thailand during 2007–2014, raising questions about the role of intra-serotypic antigenic differences in this genotype shift. We characterized the antigenic difference of DENV3 of genotypes II and III in Thailand, utilizing a neutralizing antibody assay with DENV3 vaccine sera and monotypic DENV3 sera. Although there was significant antigenic diversity among the DENV3, it did not clearly associate with the genotype. Our data therefore do not support the role of intra-serotypic antigenic difference in the genotype replacement. Amino acid alignment showed that eight positions are potentially associated with diversity between distinct antigenic subgroups. Most of these amino acids were found in envelope domain II. Some positions (aa81, aa124, and aa172) were located on the surface of virus particles, probably involving the neutralization sensitivity. Notably, the strains of both genotypes II and III showed clear antigenic differences from the vaccine genotype I strain. Whether this differencewill affect vaccine efficacy requires further studies.
ISSN:0950-2688
1469-4409
1469-4409
DOI:10.1017/S0950268823001991