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Uncovering the biotechnological capacity of marine and brackish water Planctomycetota
An appealing strategy for finding novel bioactive molecules in Nature consists in exploring underrepresented and -studied microorganisms. Here, we investigated the antimicrobial and tumoral anti-proliferative bioactivities of twenty-three marine and estuarine bacteria of the fascinating phylum Planc...
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Published in: | Antonie van Leeuwenhoek 2024-12, Vol.117 (1), p.26, Article 26 |
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Main Authors: | , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | An appealing strategy for finding novel bioactive molecules in Nature consists in exploring underrepresented and -studied microorganisms. Here, we investigated the antimicrobial and tumoral anti-proliferative bioactivities of twenty-three marine and estuarine bacteria of the fascinating phylum
Planctomycetota
. This was achieved through extraction of compounds produced by the
Planctomycetota
cultured in oligotrophic medium followed by an antimicrobial screening against ten relevant human pathogens including Gram-positive and Gram-negative bacteria, and fungi. Cytotoxic effects of the extracts were also evaluated against five tumoral cell lines. Moderate to potent activities were obtained against
Enterococcus faecalis,
methicillin-sensitive and methicillin-resistant
Staphylococcus aureus
and vancomycin-sensitive and vancomycin-resistant
Enterococcus faecium
. Anti-fungal effects were observed against
Trichophyton rubrum, Candida albicans
and
Aspergillus fumigatus
. The highest cytotoxic effects were observed against human breast, pancreas and melanoma tumoral cell lines.
Novipirellula caenicola
and
Rhodopirellula
spp. strains displayed the widest spectrum of bioactivities while
Rubinisphaera margarita
ICM_H10
T
affected all Gram-positive bacteria tested. LC-HRMS analysis of the extracts did not reveal the presence of any known bioactive natural product, suggesting that the observed activities are most likely caused by novel molecules, that need identification. In summary, we expanded the scope of planctomycetal species investigated for bioactivities and demonstrated that various strains are promising sources of novel bioactive compounds, which reenforces the potential biotechnological prospects offered by
Planctomycetota
. |
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ISSN: | 0003-6072 1572-9699 1572-9699 |
DOI: | 10.1007/s10482-023-01923-z |