Sleep duration in preschool age and later behavioral and cognitive outcomes: an individual participant data meta-analysis in five European cohorts

• Published in: European child & adolescent psychiatry 2024-01, Vol.33 (1), p.167-177
• Main Authors: Guerlich, Kathrin, Avraam, Demetris, Cadman, Tim, Calas, Lucinda, Charles, Marie-Aline, Elhakeem, Ahmed, Fernández-Barrés, Silvia, Guxens, Mònica, Heude, Barbara, Ibarluzea, Jesús, Inskip, Hazel, Julvez, Jordi, Lawlor, Deborah A., Murcia, Mario, Salika, Theodosia, Sunyer, Jordi, Tafflet, Muriel, Koletzko, Berthold, Grote, Veit, Plancoulaine, Sabine
• Format: Article
• Language: English
• Subjects: Analysis; Behavior; Causality; Child; Child and Adolescent Psychiatry; Child, Preschool; Children; Cognition; Cognitive ability; Cognitive science; Cognitive-behavioral factors; Externalizing behaviour; Humans; Intelligence; Intelligence tests; Internalization; Language; Life Sciences; Medicine; Medicine & Public Health; Meta-analysis; Original Contribution; Preschool children; Psychiatry; Regression analysis; Sleep; Sleep Duration; Statistics; Verbal intelligence; Wechsler Scales
• ISSN: 1018-8827; 1435-165X; 1435-165X
• DOI: 10.1007/s00787-023-02149-0

Short sleep duration has been linked to adverse behavioral and cognitive outcomes in schoolchildren, but few studies examined this relation in preschoolers. We aimed to investigate the association between parent-reported sleep duration at 3.5 years and behavioral and cognitive outcomes at 5 years in European children. We used harmonized data from five cohorts of the European Union Child Cohort Network: ALSPAC, SWS (UK); EDEN, ELFE (France); INMA (Spain). Associations were estimated through DataSHIELD using adjusted generalized linear regression models fitted separately for each cohort and pooled with random-effects meta-analysis. Behavior was measured with the Strengths and Difficulties Questionnaire. Language and non-verbal intelligence were assessed by the Wechsler Preschool and Primary Scale of Intelligence or the McCarthy Scales of Children’s Abilities. Behavioral and cognitive analyses included 11,920 and 2981 children, respectively (34.0%/13.4% of the original sample). In meta-analysis, longer mean sleep duration per day at 3.5 years was associated with lower mean internalizing and externalizing behavior percentile scores at 5 years (adjusted mean difference: − 1.27, 95% CI [− 2.22, − 0.32] / − 2.39, 95% CI [− 3.04, − 1.75]). Sleep duration and language or non-verbal intelligence showed trends of inverse associations, however, with imprecise estimates (adjusted mean difference: − 0.28, 95% CI [− 0.83, 0.27] / − 0.42, 95% CI [− 0.99, 0.15]). This individual participant data meta-analysis suggests that longer sleep duration in preschool age may be important for children’s later behavior and highlight the need for larger samples for robust analyses of cognitive outcomes. Findings could be influenced by confounding or reverse causality and require replication.