Assessment of early macular microangiopathy in subjects with prediabetes using optical coherence tomography angiography and fundus photography

Aims Early detection of retinal microangiopathy in patients with prediabetes may reduce diabetic retinopathy complications. The aim of this study was to assess early macular vascular changes in prediabetics before development of over diabetes using OCTA and fundus photography. Methods In this cross-...

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Bibliographic Details
Published in:Acta diabetologica 2024-01, Vol.61 (1), p.69-77
Main Authors: El Sawy, Shereen, Bekhit, Mirrette, Abdelhamid, Alaa, Esmat, Sohair, Ashraf, Hala, Naguib, Mervat
Format: Article
Language:English
Subjects:
Angiography
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetic Retinopathy - diagnostic imaging
Diabetic Retinopathy - etiology
Fluorescein Angiography - methods
Humans
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Original
Original Article
Perfusion
Photography
Prediabetic State - diagnosis
Retina
Retinal Diseases
Retinal Vessels - diagnostic imaging
Retinopathy
Tomography, Optical Coherence - methods
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Summary:Aims Early detection of retinal microangiopathy in patients with prediabetes may reduce diabetic retinopathy complications. The aim of this study was to assess early macular vascular changes in prediabetics before development of over diabetes using OCTA and fundus photography. Methods In this cross-sectional study, 66 prediabetic individuals and 66 normal controls underwent clinical, laboratory, and fundus photography evaluation followed by OCTA macular imaging to examine for the foveal avascular zone, and area of capillary non-perfusion, thickness, disorganization of vessels, and vessel density perfusion percentage of superficial capillary plexus and deep capillary plexus. Results Retinal microangiopathy was detected in 36.4% of prediabetics by OCTA and only in 10.6% by fundus photography. None of clinical or laboratory parameters had significant association with DR. Area of capillary non-perfusion and disorganization of SCP were detected in 53.8% and 56.8%, respectively, in prediabetics. VDP of SCP and DCP of whole image, parafoveal, and perifoveal areas was significantly lower in prediabetes group compared to normal control. VDP of DCP of perifoveal area ( β coefficient: − 0.10, OR: 0.91, 95% CI: 0.86–0.96, P  
ISSN:1432-5233
0940-5429
1432-5233
DOI:10.1007/s00592-023-02167-z