Feline cutaneous mast cell tumours: a UK-based study comparing signalment and histological features with long-term outcomes

Feline cutaneous mast cell tumours (MCTs) are the second most common skin tumour in cats; but, unlike in dogs, there is currently no histological grading system for this type of tumour. This study recorded the signalment and anatomical location from a total of 287 records from MCTs submitted to a UK...

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Bibliographic Details
Published in:Journal of feline medicine and surgery 2015-06, Vol.17 (6), p.486-493
Main Authors: Melville, Kirsty, Smith, Ken C, Dobromylskyj, Melanie J
Format: Article
Language:English
Subjects:
Animals
Cat Diseases - pathology
Cat Diseases - surgery
Cats
Disease-Free Survival
Female
Male
Mastocytosis, Cutaneous - pathology
Mastocytosis, Cutaneous - surgery
Mastocytosis, Cutaneous - veterinary
Original
Prognosis
Skin - pathology
Skin Neoplasms - pathology
Skin Neoplasms - surgery
Skin Neoplasms - veterinary
United Kingdom
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Summary:Feline cutaneous mast cell tumours (MCTs) are the second most common skin tumour in cats; but, unlike in dogs, there is currently no histological grading system for this type of tumour. This study recorded the signalment and anatomical location from a total of 287 records from MCTs submitted to a UK commercial diagnostic laboratory. Questionnaires to submitting practices were used to obtain follow-up data, and the histological features of 86 tumours were evaluated from 69 cats with a known outcome. Twelve of the 69 cats (17.4%) died of MCTs, with significantly lower survival times. The median age of cats presenting with MCTs was 11 years (range 5 months–19 years), with no sex or neutered status predilection. Some pedigree breeds were more susceptible to MCTs, particularly the Siamese, Burmese, Russian Blue and Ragdoll. The head was the most common site in younger cats, compared with the trunk in older cats. The number of tumours had no effect on survival. A new subcategory of well-differentiated MCTs with prominent multinucleated cells is described, and three of the five cats with this novel form died from MCT-related disease. There was an association between mitotic index and survival time. However, there was no significant association between histological type and survival.
ISSN:1098-612X
1532-2750
1532-2750
DOI:10.1177/1098612X14548784