Sedative, hematologic and hemostatic effects of dexmedetomidine–butorphanol alone or in combination with ketamine in cats

Acute stress induced by physical restraint can interfere with the validity of laboratory findings. Sedation could minimize such stress. However, it is not known whether sedation can affect hematologic and hemostatic parameters in cats. The purpose of this study was to evaluate hematologic and hemost...

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Published in:Journal of feline medicine and surgery 2015-06, Vol.17 (6), p.500-506
Main Authors: Volpato, Julieta, Mattoso, Cláudio Roberto Scabelo, Beier, Suzane Lilian, Coelho, Mirelly Medeiros, Tocheto, Ronise, Kirsten, Cristine Elizabeth, Yonezawa, Letícia Andreza, Saito, Mere Erika
Format: Article
Language:English
Subjects:
Animals
Butorphanol - administration & dosage
Butorphanol - pharmacology
Cardiovascular System - drug effects
Cat Diseases - drug therapy
Cats
Conscious Sedation - veterinary
Dexmedetomidine - administration & dosage
Dexmedetomidine - pharmacology
Drug Combinations
Hypnotics and Sedatives - administration & dosage
Hypnotics and Sedatives - pharmacology
Ketamine - administration & dosage
Ketamine - pharmacology
Muscle Relaxation - drug effects
Original
Random Allocation
Respiration - drug effects
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Summary:Acute stress induced by physical restraint can interfere with the validity of laboratory findings. Sedation could minimize such stress. However, it is not known whether sedation can affect hematologic and hemostatic parameters in cats. The purpose of this study was to evaluate hematologic and hemostatic parameters in domestic cats subjected to physical restraint in addition to one of two sedation protocols. In total, 50 cats were subjected to physical restraint and were then randomly divided into two groups of 25 animals, receiving dexmedetomidine (5 µg/kg) and butorphanol (0.3 mg/kg; DB group) or dexmedetomidine (5 µg/kg), butorphanol (0.3 mg/kg) and ketamine (3 mg/kg; DBK group). The cats were assessed for acute stress, sedation level, onset of sedation and duration of sedation. Blood samples were collected after handling and after sedation. The complete blood count (CBC), platelet count, buccal mucosal bleeding time (BMBT), whole-blood clotting time, prothrombin time (PT), activated partial thromboplastin time (aPTT) and thrombin time (TT) were determined for each sample, before and after chemical restraint. No statistically significant differences were found in the hematologic parameters. Certain hemostatic parameters (PT, aPTT and TT) were higher in the DB group (P
ISSN:1098-612X
1532-2750
1532-2750
DOI:10.1177/1098612X14549214