Plasma histamine concentration and histamine detection in peripheral blood eosinophils in cats

Plasma histamine levels were measured in 11 clinically healthy cats and 15 cats with allergic dermatitis. Histamine levels were markedly elevated in 5/15 allergic cats. A calcium ionophore, A23187, stimulates histamine release from feline peripheral blood cells. Immunostaining of blood smears from c...

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Bibliographic Details
Published in:Journal of feline medicine and surgery 2006-10, Vol.8 (5), p.302-308
Main Authors: Kadoya, Michiyo, Momoi, Yasuyuki, Iwasaki, Toshiroh
Format: Article
Language:English
Subjects:
Animals
Biomarkers - analysis
Cat Diseases - immunology
Cat Diseases - pathology
Cats
Dermatitis, Allergic Contact - immunology
Dermatitis, Allergic Contact - pathology
Dermatitis, Allergic Contact - veterinary
Eosinophils - immunology
Female
Histamine - blood
Histamine Release
Male
Reproducibility of Results
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Summary:Plasma histamine levels were measured in 11 clinically healthy cats and 15 cats with allergic dermatitis. Histamine levels were markedly elevated in 5/15 allergic cats. A calcium ionophore, A23187, stimulates histamine release from feline peripheral blood cells. Immunostaining of blood smears from clinically healthy cats revealed that approximately 10% of eosinophils possessed histamine-containing granules. These results indicate that some peripheral eosinophils in cats contain histamine and can release histamine by appropriate stimulation.
ISSN:1098-612X
1532-2750
DOI:10.1016/j.jfms.2006.02.006