Life's essential 8 and risk of all‐cause mortality in individuals with cardiovascular diseases: A prospective community‐based study

• Published in: Clinical cardiology (Mahwah, N.J.) N.J.), 2024-02, Vol.47 (2), p.e24119-n/a
• Main Authors: Huang, Lili, Wang, Aitian, Wu, Zhijun, Chen, Shuohua, Zheng, Yan, Wu, Shouling, Gao, Xiang
• Format: Article
• Language: English
• Subjects: all‐cause mortality; Antihypertensives; Bioengineering; Blood Pressure - physiology; Body mass index; cardiovascular disease; Cardiovascular Diseases; cardiovascular health; Cholesterol; Clinical Investigations; Diet; Family medical history; Glucose; Humans; Ischemia; Lifestyles; Lipids; Metabolism; Mortality; prevention; Prospective Studies; Questionnaires; Risk Factors; Smoking; Stroke; United States
• ISSN: 0160-9289; 1932-8737; 1932-8737
• DOI: 10.1002/clc.24119

Background Although risk factors for mortality in individuals with cardiovascular diseases (CVD) have been reported, little is known regarding the association between the comprehensive cardiovascular health (CVH) index assessed by life's essential 8 (LE8) and the risk of mortality. Hypothesis The aim of this study was to evaluate the CVH assessed by LE8 and risk of mortality in individuals with CVD. Methods A total of 1391 participants with CVD diagnosed before 2014 from the Kailuan cohort were included in the analysis. The CVH score ranged from 0 to 100 was assessed using the LE8 metrics (diet quality, physical activity, sleep health, cigarette smoking, body mass index, lipids, blood glucose, and blood pressure). Cox regression model was used to estimate the association between the CVH score and risk of all‐cause mortality. Results During a mean follow‐up of 6.1 ± 1.5 years, 229 deaths occurred. The hazard ratio for all‐cause mortality was 0.57 (95% confidence interval [CI]: 0.38, 0.84) in the highest quartiles compared with the lowest quartiles of CVH scores and 0.85 (95% CI: 0.75, 0.95) for each 10 points increment in CVH scores (ptrend = .009), after adjustment for age, sex, CVD duration, social‐economic status, alcohol consumption, inflammation, medicine use, and kidney function. We did not observe significant interactions between the CVH scores and age, sex, and duration of CVD diagnosis (pinteraction > .05 for all). Conclusions The CVH assessed by the LE8 metrics was associated with a lower risk of all‐cause mortality in individuals with CVD. In this cohort study of 1391 participants with cardiovascular diseases from the Kailuan cohort in China, the cardiovascular health (CVH) was assessed by life's essential 8. Participants with the highest CVH scores compared with the lowest CVH scores had nearly 50% lower risk for all‐cause mortality.