Lactate dehydrogenase‐to‐albumin ratio: A superior inflammatory marker for predicting contrast‐associated acute kidney injury after percutaneous coronary intervention

Purpose Inflammation is commonly considered a mechanism underlying contrast‐associated acute kidney injury (CA‐AKI). This study aimed to explore the predictive capability of the novel inflammatory marker lactate dehydrogenase‐to‐albumin ratio (LAR) for CA‐AKI following percutaneous coronary interven...

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Published in:Clinical cardiology (Mahwah, N.J.) N.J.), 2024-02, Vol.47 (2), p.e24219-n/a
Main Authors: Zeng, Ji‐Lang, Chen, Jun‐Han, Zhang, Li‐Wei, Chen, Li‐Chuan, Liang, Wen‐Jia, You, Zhebin, Lin, Kai‐Yang, Guo, Yansong
Format: Article
Language:English
Subjects:
Acute Kidney Injury - chemically induced
Acute Kidney Injury - diagnosis
Albumins
all‐cause mortality
Anemia
Angioplasty
Biomarkers
Blood
Blood platelets
Cardiovascular disease
Clinical
Contrast agents
contrast‐associated acute kidney injury
Creatinine
Dehydrogenases
Diabetes
Females
Heart attacks
Heart failure
Humans
Hypertension
Hypotension
Inflammation
Intervention
Kidney diseases
Lactate Dehydrogenases
lactate dehydrogenase‐to‐albumin ratio
Lymphocytes
Medical prognosis
Medical records
Mortality
Neutrophils
Normal distribution
percutaneous coronary intervention
Percutaneous Coronary Intervention - adverse effects
Regression analysis
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Summary:Purpose Inflammation is commonly considered a mechanism underlying contrast‐associated acute kidney injury (CA‐AKI). This study aimed to explore the predictive capability of the novel inflammatory marker lactate dehydrogenase‐to‐albumin ratio (LAR) for CA‐AKI following percutaneous coronary intervention (PCI), and further compare it with other common inflammatory biomarkers. Methods This study enrolled 5,435 patients undergoing elective PCI. The primary outcome was CA‐AKI, and the secondary outcome was all‐cause mortality. All patients were grouped into three groups based on the LAR tertiles. Results Three hundred fifteen patients (5.8%) experienced CA‐AKI during hospitalization. The fully adjusted logistic regression suggested a significant increase in the risk of CA‐AKI in LAR Tertile 3 (odds ratio [OR]: 2.51, 95% confidence interval [CI]: 1.68−3.83, p 
ISSN:0160-9289
1932-8737
1932-8737
DOI:10.1002/clc.24219