Association between CLOCK gene polymorphisms and ADHD in Mexican teenagers: A comprehensive assessment

• Published in: Psychiatry research 2022-11, Vol.317, p.114835-114835, Article 114835
• Main Authors: Cabrera Lagunes, Alfonso, Díaz-Anzaldúa, Adriana, Rojas Andrade, Gustavo, Peschard, Vanessa-Giselle, Arias Caballero, Adriana, Gaspar-Barba, César Enrique, Yunes Jimenez, Arlette, De la Peña Olvera, Francisco Rafael, Cruz Fuentes, Carlos Sabas, Feria-Aranda, Miriam, Sosa Mora, Liz, Pérez Molina, Armando, Guizar Sanchez, Diana, Palacios-Cruz, Lino
• Format: Article
• Language: English
• Subjects: Adolescent; Attention deficit disorder with hyperactivity; Attention Deficit Disorder with Hyperactivity - genetics; Circadian rhythm; CLOCK Proteins - genetics; Female; Genotype; Humans; Male; Polymorphism, Single Nucleotide - genetics; Risk factors; Single nucleotide polymorphism; Thyroxine; Triiodothyronine
• ISSN: 0165-1781; 1872-7123; 1872-7123
• DOI: 10.1016/j.psychres.2022.114835

This study aimed to evaluate markers of the CLOCK gene rs1801260 and rs4864548 in Mexican adolescents, addressing clinical and biological aspects previously associated with ADHD. 347 Mexican adolescents were assessed for mental disorders, metabolic disruption and related conditions, circadian preference, as well as genotyping for the CLOCK. We found a significant association between ADHD and the AA and AG genotypes of rs1801260. Also, we identified in the ADHD group that the total Triiodothyronine and total Thyroxine values were respectively 10 ng/dl units and 0.58 ug/dl units lower in females than in males. Previously reported common variations of the CLOCK gene have been associated with ADHD like the Rs1801260 polymorphism hereby we could consider it as risk factor, but genetic, biochemical and clinical studies in the Mexican population are entailed.