Bioinformatics analysis of GPS1 expression and biological function in breast cancer

G protein pathway suppressor 1 (GPS1) is involved in the development of many diseases including tumors, but its specific regulatory mechanism in breast cancer is not clear. The goal of the present study was to explore the biological effects and underlying mechanism of GPS1 in breast cancer. Public d...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2024-01, Vol.150 (2), p.52-52, Article 52
Main Authors: Wei, Hong, Niu, Zhaocan, Ji, Ruixue, Jiang, Wenwen, Tang, Jiawei, Meng, Zhexuan, Cao, Xiaoyang, Zhang, Xinyi, Liu, Xue
Format: Article
Language:English
Subjects:
Bioinformatics
Breast
Breast cancer
breast neoplasms
Breast Neoplasms - genetics
breasts
Cancer Research
Cell proliferation
Computational Biology
COP9 Signalosome Complex - genetics
Databases, Factual
Female
Hematology
Humans
Immunotherapy
Internal Medicine
mechanism of action
Medical prognosis
Medicine
Medicine & Public Health
Microenvironments
neoplasm progression
Oncology
Prognosis
ribonucleoproteins
RNA
Trans-Activators
Tumor Microenvironment
Wnt protein
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Summary:G protein pathway suppressor 1 (GPS1) is involved in the development of many diseases including tumors, but its specific regulatory mechanism in breast cancer is not clear. The goal of the present study was to explore the biological effects and underlying mechanism of GPS1 in breast cancer. Public databases were used to analyze GPS1 expression and the relationship with clinicopathological characteristics and prognosis of breast cancer patients, combined with in vitro experiments to analyze the mechanism of action and immune relevance of GPS1 in breast cancer. Data analysis showed that the expression of GPS1 in breast cancer tissues was significantly higher than that in paracancerous tissues ( p  
ISSN:1432-1335
0171-5216
1432-1335
DOI:10.1007/s00432-023-05569-2