Bioinformatics analysis of GPS1 expression and biological function in breast cancer

G protein pathway suppressor 1 (GPS1) is involved in the development of many diseases including tumors, but its specific regulatory mechanism in breast cancer is not clear. The goal of the present study was to explore the biological effects and underlying mechanism of GPS1 in breast cancer. Public d...

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Published in:Journal of cancer research and clinical oncology 2024-01, Vol.150 (2), p.52-52, Article 52
Main Authors: Wei, Hong, Niu, Zhaocan, Ji, Ruixue, Jiang, Wenwen, Tang, Jiawei, Meng, Zhexuan, Cao, Xiaoyang, Zhang, Xinyi, Liu, Xue
Format: Article
Language:English
Subjects:
Bioinformatics
Breast
Breast cancer
breast neoplasms
Breast Neoplasms - genetics
breasts
Cancer Research
Cell proliferation
Computational Biology
COP9 Signalosome Complex - genetics
Databases, Factual
Female
Hematology
Humans
Immunotherapy
Internal Medicine
mechanism of action
Medical prognosis
Medicine
Medicine & Public Health
Microenvironments
neoplasm progression
Oncology
Prognosis
ribonucleoproteins
RNA
Trans-Activators
Tumor Microenvironment
Wnt protein
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container_start_page 52
container_title Journal of cancer research and clinical oncology
container_volume 150
creator Wei, Hong
Niu, Zhaocan
Ji, Ruixue
Jiang, Wenwen
Tang, Jiawei
Meng, Zhexuan
Cao, Xiaoyang
Zhang, Xinyi
Liu, Xue
description G protein pathway suppressor 1 (GPS1) is involved in the development of many diseases including tumors, but its specific regulatory mechanism in breast cancer is not clear. The goal of the present study was to explore the biological effects and underlying mechanism of GPS1 in breast cancer. Public databases were used to analyze GPS1 expression and the relationship with clinicopathological characteristics and prognosis of breast cancer patients, combined with in vitro experiments to analyze the mechanism of action and immune relevance of GPS1 in breast cancer. Data analysis showed that the expression of GPS1 in breast cancer tissues was significantly higher than that in paracancerous tissues ( p  
doi_str_mv 10.1007/s00432-023-05569-2
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The goal of the present study was to explore the biological effects and underlying mechanism of GPS1 in breast cancer. Public databases were used to analyze GPS1 expression and the relationship with clinicopathological characteristics and prognosis of breast cancer patients, combined with in vitro experiments to analyze the mechanism of action and immune relevance of GPS1 in breast cancer. Data analysis showed that the expression of GPS1 in breast cancer tissues was significantly higher than that in paracancerous tissues ( p  &lt; 0.001), and the receiver operating curve (ROC) revealed a higher diagnostic efficiency (AUC = 0.832). Survival analyses indicated that patients with high GPS1 expression made the prognosis worse in Luminal B, low to intermediate-grade breast cancers. Enrichment analysis showed that GPS1 was involved in the formation of ribonucleoprotein complexes, which dynamically altered the fate of RNA; it could also enhance the responsiveness of the Wnt pathway by interacting with WBP2. In addition, GPS1 expression was closely related to the immune microenvironment. GPS1 knockdown inhibits the proliferation, invasion and migration of MCF7 and MDA-MB-231 cells in vitro. This study suggests that the upregulation of GPS1 is associated with the malignant biological behavior and prognosis of breast cancer and may promote cancer progression. 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Enrichment analysis showed that GPS1 was involved in the formation of ribonucleoprotein complexes, which dynamically altered the fate of RNA; it could also enhance the responsiveness of the Wnt pathway by interacting with WBP2. In addition, GPS1 expression was closely related to the immune microenvironment. GPS1 knockdown inhibits the proliferation, invasion and migration of MCF7 and MDA-MB-231 cells in vitro. This study suggests that the upregulation of GPS1 is associated with the malignant biological behavior and prognosis of breast cancer and may promote cancer progression. The correlation between GPS1 and the immune microenvironment suggests that it may be a potential target for immunotherapy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38289496</pmid><doi>10.1007/s00432-023-05569-2</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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source Springer Nature; Springer Nature - SpringerLink Journals - Fully Open Access
subjects Bioinformatics
Breast
Breast cancer
breast neoplasms
Breast Neoplasms - genetics
breasts
Cancer Research
Cell proliferation
Computational Biology
COP9 Signalosome Complex - genetics
Databases, Factual
Female
Hematology
Humans
Immunotherapy
Internal Medicine
mechanism of action
Medical prognosis
Medicine
Medicine & Public Health
Microenvironments
neoplasm progression
Oncology
Prognosis
ribonucleoproteins
RNA
Trans-Activators
Tumor Microenvironment
Wnt protein
title Bioinformatics analysis of GPS1 expression and biological function in breast cancer
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