Minichromosome maintenance protein 5 - a promising prognostic marker of oral epithelial dysplasias and oral squamous cell carcinomas

Early diagnosis is the single most effective means of reducing the mortality rate of oral cancer. This study was undertaken to assess the expression of minichromosome maintenance protein 5 (MCM5) in oral epithelial dysplasias and oral squamous cell carcinomas (OSCCs) and to evaluate their possible r...

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Published in:Journal of oral and maxillofacial pathology : JOMFP 2023-10, Vol.27 (4), p.655-662
Main Authors: Mathew, Lisha, Janardhanan, Mahija, Suresh, Rakesh, Savithri, Vindhya, Aravind, Thara, Aiswarya, A
Format: Article
Language:English
Subjects:
Biomarkers
Cancer
Diagnosis
Dysplasia
Hyperplasia
Labeling
MCM5 protein
Oncology, Experimental
Oral cancer
Oral carcinoma
Oral squamous cell carcinoma
Original
Prognosis
Proteins
Squamous cell carcinoma
Statistical analysis
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Summary:Early diagnosis is the single most effective means of reducing the mortality rate of oral cancer. This study was undertaken to assess the expression of minichromosome maintenance protein 5 (MCM5) in oral epithelial dysplasias and oral squamous cell carcinomas (OSCCs) and to evaluate their possible role as a biomarker for early diagnosis and prognosis of OSCC. A retrospective cross-sectional study. The study was conducted to assess the expression of MCM5 immunohistochemically in the tissue samples of oral epithelial dysplasias ( = 27) and OSCCs ( = 30) diagnosed between 2014 and 2019. The difference in the mean nuclear labelling index (LI) between the groups and the subgroups was analysed statistically using the Kruskal-Wallis test and the test, and the Dunn-Bonferroni multiple comparison analysis was conducted for pairwise comparison between the four main groups and the subgroups. The association between mean MCM5 LI and clinicopathological parameters was analysed using Spearman's rank correlation coefficient. A progressive increase in the nuclear expression of MCM5 protein ( -value
ISSN:0973-029X
1998-393X
DOI:10.4103/jomfp.jomfp_456_23