Imperatorin interacts additively with novel antiseizure medications in the mouse maximal electroshock-induced seizure model: an isobolographic transformation

Background Anticonvulsant effects of imperatorin (IMP) have been experimentally confirmed earlier, but no information is available on the interaction profiles of this naturally occurring coumarin when combined with novel antiseizure medication (ASMs). This study aimed to determine the effects of IMP...

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Bibliographic Details
Published in:Pharmacological reports 2024-02, Vol.76 (1), p.216-222
Main Authors: Łuszczki, Jarogniew J., Kochman-Moskal, Ewelina, Bojar, Hubert, Florek-Łuszczki, Magdalena, Skalicka-Woźniak, Krystyna
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants - therapeutic use
Brain
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Interactions
Drug Safety and Pharmacovigilance
Electroshock
Furocoumarins - pharmacology
Furocoumarins - therapeutic use
Lacosamide
Medicine
Mice
Oxcarbazepine - therapeutic use
Pharmacotherapy
Pharmacy
Seizures - drug therapy
Short Communication
Topiramate - pharmacology
Topiramate - therapeutic use
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Summary:Background Anticonvulsant effects of imperatorin (IMP) have been experimentally confirmed earlier, but no information is available on the interaction profiles of this naturally occurring coumarin when combined with novel antiseizure medication (ASMs). This study aimed to determine the effects of IMP on the anticonvulsant effects of lacosamide (LCM), oxcarbazepine (OXC), pregabalin (PGB), and topiramate (TPM) in the maximal electroshock-induced seizure (MES) model in mice. Methods The anticonvulsant effects exerted by novel ASMs (LCM, OXC, PGB, and TPM) when combined with constant doses of IMP (25 and 50 mg/kg) underwent isobolographic transformation to precisely classify the observed interactions in the mouse MES model. Total brain concentrations of ASMs were measured with high-pressure liquid chromatography to exclude the pharmacokinetic nature of interactions among IMP and the tested ASMs. Results IMP (50 mg/kg) significantly enhanced ( p  
ISSN:1734-1140
2299-5684
2299-5684
DOI:10.1007/s43440-023-00555-4