Perioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in cats

A randomized double blind and placebo controlled design was used to investigate the hemostatic, biochemical, gastrointestinal and behavioral effects of pre- and postoperative administration of vedaprofen 0.5 mg/kg PO (V), tramadol 2 mg/kg SC (T), their association (VT) or placebo (P) in 40 adult fem...

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Bibliographic Details
Published in:Journal of feline medicine and surgery 2009-06, Vol.11 (6), p.503-509
Main Authors: Brondani, Juliana T., Luna, Stelio P.L., Marcello, Gracy C.G., Padovani, Carlos R.
Format: Article
Language:English
Subjects:
adverse effects
analgesics
Analgesics - therapeutic use
Analgesics, Non-Narcotic - therapeutic use
Animals
Cat Diseases - drug therapy
Cats
combination drug therapy
Double-Blind Method
Drug Therapy, Combination
Female
Hysterectomy - veterinary
Naphthalenes - administration & dosage
narcotics
nonsteroidal anti-inflammatory agents
Ovariectomy - veterinary
Pain Measurement - veterinary
Pain, Postoperative - prevention & control
Pain, Postoperative - veterinary
Platelet Aggregation - drug effects
Postoperative Hemorrhage - prevention & control
Postoperative Hemorrhage - veterinary
Propionates - administration & dosage
spaying
Tramadol - administration & dosage
Treatment Outcome
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Summary:A randomized double blind and placebo controlled design was used to investigate the hemostatic, biochemical, gastrointestinal and behavioral effects of pre- and postoperative administration of vedaprofen 0.5 mg/kg PO (V), tramadol 2 mg/kg SC (T), their association (VT) or placebo (P) in 40 adult female cats (3.0 ± 0.32 kg; 1.8 ± 0.7 years) distributed in groups of 10. Platelet aggregation and bleeding time were measured before and 52 h after ovariohysterectomy. Serum urea, creatinine, alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transferase concentrations were measured before and 7 days postoperatively. The occurrence of vomiting, frequency and consistency of feces, and behavior were observed for 7 days postoperatively. Morphine (0.5 mg/kg, IM) was used as rescue analgesic. Laboratory variables did not change. Vomiting was observed only after morphine administration. Mild euphoria was observed in T and VT. The perioperative use of vedaprofen and/or tramadol did not modify the hemostatic, biochemical and gastrointestinal function in cats.
ISSN:1098-612X
1532-2750
DOI:10.1016/j.jfms.2008.12.003