Zinc-Boron Complex-Based Dietary Supplements for Longevity and Healthy Life

The nutritional role of zinc (Zn) and boron (B) in the plant-animal-human food chain is highly topical worldwide research. Our data indicated that Zn-B complex (ZBC)-based dietary supplements can be used as stable non-toxic formulations, with high intestinal absorption rate, inducing alpha2-macroglo...

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Published in:Current health sciences journal 2023-07, Vol.49 (3), p.381-387
Main Authors: Biţă, Andrei, Scorei, Ion Romulus, Bălşeanu, Tudor Adrian, Rău, Gabriela, Ciocîlteu, Maria Viorica, Mogoşanu, George Dan
Format: Article
Language:English
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Summary:The nutritional role of zinc (Zn) and boron (B) in the plant-animal-human food chain is highly topical worldwide research. Our data indicated that Zn-B complex (ZBC)-based dietary supplements can be used as stable non-toxic formulations, with high intestinal absorption rate, inducing alpha2-macroglobulin (A2M) expression for longevity and healthy life. ZBC is metabolized by hydrolysis, mainly at the absorption site (intestinal level), and most of it is excreted in the urine. Within seven hours from the administration in mice, almost the entire amount of orally absorbed ZBC is eliminated in a metabolized form. The highest amount of A2M protein in mouse liver was determined by immunoabsorbance assay in the chronic experiment (1000mg/kg of ZBC), followed by the subchronic experiment (at the same dose of ZBC), and by the acute experiment (5000mg/kg of ZBC).
ISSN:2067-0656
2069-4032
DOI:10.12865/CHSJ.49.03.10