Comparison of two cognitive screening measures in a longitudinal sample of youth at-risk for psychosis

Validated screening tools are needed to detect subtle cognitive impairment in individuals at-risk for developing psychosis. Here, the utility of the Mini-Mental Status Examination (MMSE) and Penn Computerized Neurocognitive Battery (CNB) were evaluated for detecting cognitive impairment in individua...

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Bibliographic Details
Published in:Schizophrenia research 2022-08, Vol.246, p.216-224
Main Authors: Kantor, Jenna R., Gur, Ruben C., Calkins, Monica E., Moore, Tyler M., Port, Allison M., Ruparel, Kosha, Scott, J. Cobb, Troyan, Scott, Gur, Raquel E., Roalf, David R.
Format: Article
Language:English
Subjects:
Adolescent
At-risk
Cognition
Cognitive Dysfunction - diagnosis
Cognitive Dysfunction - epidemiology
Cognitive Dysfunction - etiology
Female
Humans
Male
Mental Status and Dementia Tests
MMSE
Neuropsychological Tests
Penn computerized neurocognitive battery
Psychosis
Psychotic Disorders - complications
Psychotic Disorders - diagnosis
ROC Curve
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Summary:Validated screening tools are needed to detect subtle cognitive impairment in individuals at-risk for developing psychosis. Here, the utility of the Mini-Mental Status Examination (MMSE) and Penn Computerized Neurocognitive Battery (CNB) were evaluated for detecting cognitive impairment in individuals with psychosis spectrum (PS) symptoms. Participants (n = 229; 54 % female) completed the MMSE and CNB at baseline and two-year follow-up. PS (n = 91) and typically developing (TD; n = 138) participants were enrolled at baseline based on the presence or absence of PS symptoms. After two years, 65 participants remained PS, 104 participants remained TD, 23 participants had Emergent (EP) subthreshold PS symptoms, and 37 participants were experiencing Other Psychopathology (OP). Generally, those with PS had lower scores than TD on both the MMSE (p 
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2022.06.017