The association between gut microbiome and growth in infants with cystic fibrosis

In cystic fibrosis (CF), pathophysiologic changes in the gastrointestinal tract lead to malnutrition and altered gut microbiome. Microbiome alterations have been linked to linear growth, gut inflammation and respiratory manifestations. Elucidating these gut microbiome alterations may provide insight...

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Published in:Journal of cystic fibrosis 2023-11, Vol.22 (6), p.1010-1016
Main Authors: Deschamp, A R, Chen, Y, Wang, W F, Rasic, M, Hatch, J, Sanders, D B, Ranganathan, S C, Ferkol, T, Perkins, D, Finn, P, Davis, S D
Format: Article
Language:English
Subjects:
Cystic Fibrosis - complications
Feces - microbiology
Female
Gastrointestinal Microbiome
Gastrointestinal Tract
Humans
Infant
Malnutrition - diagnosis
Malnutrition - etiology
RNA, Ribosomal, 16S - genetics
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Summary:In cystic fibrosis (CF), pathophysiologic changes in the gastrointestinal tract lead to malnutrition and altered gut microbiome. Microbiome alterations have been linked to linear growth, gut inflammation and respiratory manifestations. Elucidating these gut microbiome alterations may provide insight into future nutritional management in CF. Infants were followed for 12-months at four sites in the United States (US-CF) and Australia (AUS-CF). 16S rRNA gene sequencing was performed on longitudinal stool samples. Associations between microbial abundance and age, antibiotic prophylaxis, malnutrition, and breast feeding were evaluated using generalized linear mixed models. Taxonomic and predictive functional features were compared between groups. Infants with CF (N = 78) were enrolled as part of a larger study. AUS-CF infants had higher mean weight-for-age z-scores than US-CF infants (p = 0.02). A subset of participants (CF N = 40, non-CF disease controls N = 10) provided stool samples for microbiome analysis. AUS-CF infants had lower stool alpha diversity compared to US-CF infants (p 
ISSN:1569-1993
1873-5010
1873-5010
DOI:10.1016/j.jcf.2023.08.001