Mini- and microsatellite expansions: the recombination connection

It is widely accepted that the large trinucleotide repeat expansions observed in many neurological diseases occur during replication. However, genetic recombination has emerged as a major source of instability for tandem repeats, including minisatellites, and recent studies raise the possibility tha...

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Bibliographic Details
Published in:EMBO reports 2000-08, Vol.1 (2), p.122-126
Main Authors: Richard, Guy-Franck, Pâques, Frédéric
Format: Article
Language:English
Subjects:
Animals
DNA - genetics
DNA Repair
Gene Conversion
Humans
Meiosis - genetics
Meiosis - physiology
Minisatellite Repeats
Models, Genetic
Recombination, Genetic - genetics
Review
Reviews
Tandem Repeat Sequences - genetics
Trinucleotide Repeat Expansion
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Summary:It is widely accepted that the large trinucleotide repeat expansions observed in many neurological diseases occur during replication. However, genetic recombination has emerged as a major source of instability for tandem repeats, including minisatellites, and recent studies raise the possibility that it may also be responsible for trinucleotide repeat expansions. We will review data connecting tandem repeat rearrangements and recombination in humans and in eukaryotic model organisms, and discuss the possible role of recombination in trinucleotide repeat expansions in human neurological disorders.
ISSN:1469-221X
1469-3178
DOI:10.1093/embo-reports/kvd031