The Significance of Hematuria in Podocytopathies

Hematuria is frequently present in podocytopathies, but its significance and prognostic value is not well described in these proteinuric kidney diseases. This study describes the prevalence and association between hematuria and kidney-related outcomes in these disorders. Hematuria was assessed at th...

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Bibliographic Details
Published in:Clinical journal of the American Society of Nephrology 2024-01, Vol.19 (1), p.56-66
Main Authors: Marchel, Dorota, Trachtman, Howard, Larkina, Maria, Helmuth, Margaret, Lai Yee, Jennifer Y, Fermin, Damian, Bomback, Andrew S, Canetta, Pietro A, Gipson, Debbie S, Mottl, Amy K, Parekh, Rulan S, Saha, Manish K, Sampson, Matthew G, Lafayette, Richard A, Mariani, Laura H
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Female
Glomerular and Tubulointerstitial Diseases
Glomerular Filtration Rate
Glomerulonephritis, Membranous - complications
Glomerulonephritis, Membranous - urine
Glomerulosclerosis, Focal Segmental - complications
Glomerulosclerosis, Focal Segmental - epidemiology
Glomerulosclerosis, Focal Segmental - urine
Hematuria - etiology
Hematuria - urine
Humans
Male
Middle Aged
Nephrosis, Lipoid - complications
Nephrosis, Lipoid - epidemiology
Nephrosis, Lipoid - urine
Original
Podocytes - pathology
Prevalence
Prognosis
Proteinuria - etiology
Proteinuria - urine
Time Factors
Young Adult
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Summary:Hematuria is frequently present in podocytopathies, but its significance and prognostic value is not well described in these proteinuric kidney diseases. This study describes the prevalence and association between hematuria and kidney-related outcomes in these disorders. Hematuria was assessed at the initial urinalysis in participants with the following podocytopathies-membranous nephropathy, minimal change disease, and FSGS-in the Nephrotic Syndrome Study Network and Cure Glomerulonephropathy cohorts with >24 months of follow-up. Multivariable Cox proportional hazards models were fit for time to composite outcome (kidney failure or 40% decline in eGFR and eGFR
ISSN:1555-9041
1555-905X
1555-905X
DOI:10.2215/CJN.0000000000000309