Age-Dependent Variations in Kawasaki Disease Incidence in Japan

The etiology of Kawasaki disease (KD) remains elusive, with immunologic and epidemiologic data suggesting different triggers in individuals who are genetically susceptible. KD remains the most common cause of acquired heart disease in pediatric patients, and Japan is the country of highest incidence...

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Bibliographic Details
Published in:JAMA network open 2024-02, Vol.7 (2), p.e2355001
Main Authors: DeHaan, Laurel L, Copeland, Charles D, Burney, Jennifer A, Nakamura, Yosikazu, Yashiro, Mayumi, Shimizu, Chisato, Miyata, Koichi, Burns, Jane C, Cayan, Daniel R
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age groups
Child
Children & youth
Cross-Sectional Studies
Female
Humans
Incidence
Infant
Japan - epidemiology
Kawasaki disease
Male
Morbidity
Mucocutaneous Lymph Node Syndrome - epidemiology
Online Only
Original Investigation
Pediatrics
Teenagers
Toddlers
Young Adult
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Summary:The etiology of Kawasaki disease (KD) remains elusive, with immunologic and epidemiologic data suggesting different triggers in individuals who are genetically susceptible. KD remains the most common cause of acquired heart disease in pediatric patients, and Japan is the country of highest incidence, with an increasing number of cases. To investigate whether an analysis of the epidemiologic KD record in Japan stratified by age and prefecture (subregion) may yield new clues regarding mechanisms of exposure to etiologic agents associated with KD. This cross-sectional study was conducted using a dataset of patients with KD with detailed information on location and age at onset created through nationwide surveys of hospitals caring for pediatric patients with KD throughout Japan. Pediatric patients hospitalized in Japan for KD from 1970 to 2020 were included. Data were analyzed from January 2022 to January 2024. Pediatric patients with KD. The KD dataset was analyzed by patient age (infants [aged
ISSN:2574-3805
2574-3805
DOI:10.1001/jamanetworkopen.2023.55001