Notochordal cells: A potential therapeutic option for intervertebral disc degeneration

Intervertebral disc degeneration (IDD) is a prevalent musculoskeletal degenerative disorder worldwide, and ~40% of chronic low back pain cases are associated with IDD. Although the pathogenesis of IDD remains unclear, the reduction in nucleus pulposus cells (NPCs) and degradation of the extracellula...

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Bibliographic Details
Published in:Cell proliferation 2024-02, Vol.57 (2), p.e13541-n/a
Main Authors: Li, Yanhu, Zhang, Haijun, Zhu, Daxue, Yang, Fengguang, Wang, Zhaoheng, Wei, Ziyan, Yang, Zhili, Jia, Jingwen, Kang, Xuewen
Format: Article
Language:English
Subjects:
Anti-inflammatory agents
Apoptosis
Biomarkers
Cartilage
Cell Proliferation
Collagen
Degeneration
Degenerative disc disease
Extracellular matrix
Growth factors
Homeostasis
Humans
Inflammation
Intervertebral Disc - pathology
Intervertebral Disc Degeneration - metabolism
Intervertebral discs
Low back pain
Morphology
Notochord
Notochord - metabolism
Notochord - pathology
Nucleus pulposus
Nucleus Pulposus - metabolism
Pathogenesis
Review
Secretions
Signal transduction
Vertebrae
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Summary:Intervertebral disc degeneration (IDD) is a prevalent musculoskeletal degenerative disorder worldwide, and ~40% of chronic low back pain cases are associated with IDD. Although the pathogenesis of IDD remains unclear, the reduction in nucleus pulposus cells (NPCs) and degradation of the extracellular matrix (ECM) are critical factors contributing to IDD. Notochordal cells (NCs), derived from the notochord, which rapidly degrades after birth and is eventually replaced by NPCs, play a crucial role in maintaining ECM homeostasis and preventing NPCs apoptosis. Current treatments for IDD only provide symptomatic relief, while lacking the ability to inhibit or reverse its progression. However, NCs and their secretions possess anti‐inflammatory properties and promote NPCs proliferation, leading to ECM formation. Therefore, in recent years, NCs therapy targeting the underlying cause of IDD has emerged as a novel treatment strategy. This article provides a comprehensive review of the latest research progress on NCs for IDD, covering their biological characteristics, specific markers, possible mechanisms involved in IDD and therapeutic effects. It also highlights significant future directions in this field to facilitate further exploration of the pathogenesis of IDD and the development of new therapies based on NCs strategies. The biological process of NCs development into NPCs and its cell structure changes.
ISSN:0960-7722
1365-2184
DOI:10.1111/cpr.13541