Association of interpregnancy interval with adverse pregnancy outcomes according to the outcomes of the preceding pregnancy: a longitudinal study with 4.7 million live births from Brazil

SummaryBackgroundEarlier studies have proposed a link between the Interpregnancy Interval (IPI) and unfavorable birth outcomes. However, it remains unclear if the outcomes of previous births could affect this relationship. We aimed to investigate whether the occurrence of adverse outcomes–small for...

Full description

Saved in:
Bibliographic Details
Published in:Lancet Regional Health - Americas (Online) 2024-02, Vol.30, p.100687-100687, Article 100687
Main Authors: Tedde, João Guilherme G, Cerqueira-Silva, Thiago, Lagrosa Garcia, Sidney A, Amira, Brenda V, Rodrigues, Laura C, Barreto, Mauricio L, Rocha, Aline S, de Cássia Ribeiro-Silva, Rita, Falcão, Ila R, Paixao, Enny S
Format: Article
Language:English
Subjects:
Birth spacing
Internal Medicine
Interpregnancy interval
Low birth weight
Perinatal outcomes
Preterm
Public Health
Small-for-gestational-age
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c462t-efc9120e8cf9bc64fc321f715a381f3a943af321beb77a0c5025687bb8c91e203
container_end_page 100687
container_issue
container_start_page 100687
container_title Lancet Regional Health - Americas (Online)
container_volume 30
creator Tedde, João Guilherme G
Cerqueira-Silva, Thiago
Lagrosa Garcia, Sidney A
Amira, Brenda V
Rodrigues, Laura C
Barreto, Mauricio L
Rocha, Aline S
de Cássia Ribeiro-Silva, Rita
Falcão, Ila R
Paixao, Enny S
description SummaryBackgroundEarlier studies have proposed a link between the Interpregnancy Interval (IPI) and unfavorable birth outcomes. However, it remains unclear if the outcomes of previous births could affect this relationship. We aimed to investigate whether the occurrence of adverse outcomes–small for gestational age (SGA), preterm birth (PTB), and low birth weight (LBW)–at the immediately preceding pregnancy could alter the association between IPI and the same outcomes at the subsequent pregnancy. MethodsWe used a population-based linked cohort from Brazil (2001–2015). IPI was measured as the difference, in months, between the preceding birth and subsequent conception. Outcomes included SGA (
doi_str_mv 10.1016/j.lana.2024.100687
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10850771</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2667193X24000140</els_id><sourcerecordid>2924995967</sourcerecordid><originalsourceid>FETCH-LOGICAL-c462t-efc9120e8cf9bc64fc321f715a381f3a943af321beb77a0c5025687bb8c91e203</originalsourceid><addsrcrecordid>eNp9kstu1DAUhiMEolXpC7BAXrKZwZckjhECtRU3qRILQGJnOZ7jGQ-OPdjOoOHReDocUqaFBStfzv__x_J3quoxwUuCSftsu3TKqyXFtC4XuO34veqUti1fEMG-3L-zP6nOU9pijGnHGcPiYXXCOsaoYO1p9fMipaCtyjZ4FAyyPkPcRVh75fVhPu6VQ99t3iC12kNMgG7rYcw6DJCQ0jrElfVrlAPKG7itlNDpXDwafguO7udIIRf82uaxFEqTVDaHuVW95Giwzk3PcnYPqLcxbxIyMQzoMqof1j2qHhjlEpzfrGfV5zevP129W1x_ePv-6uJ6oeuW5gUYLQjF0Gkjet3WRjNKDCeNYh0xTImaKVOueug5V1g3mDblN_u-Kz6gmJ1Vr-bc3dgPsNLgc1RO7qIdVDzIoKz8u-LtRq7DXhLcNZhzUhKe3iTE8G2ElOVgkwZXCEIYk6SC1kI0ouVFSmepjiGlCObYh2A5gZdbOYGXE3g5gy-mJ3dfeLT8wVwEL2YBlH_aW4gyaQt-AlKwZLkK9v_5L_-xa2e91cp9hQOkbRhjwZckkYlKLD9OozdNHq3L1JEas1_lydoV</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2924995967</pqid></control><display><type>article</type><title>Association of interpregnancy interval with adverse pregnancy outcomes according to the outcomes of the preceding pregnancy: a longitudinal study with 4.7 million live births from Brazil</title><source>Elsevier ScienceDirect Journals</source><source>PubMed Central</source><creator>Tedde, João Guilherme G ; Cerqueira-Silva, Thiago ; Lagrosa Garcia, Sidney A ; Amira, Brenda V ; Rodrigues, Laura C ; Barreto, Mauricio L ; Rocha, Aline S ; de Cássia Ribeiro-Silva, Rita ; Falcão, Ila R ; Paixao, Enny S</creator><creatorcontrib>Tedde, João Guilherme G ; Cerqueira-Silva, Thiago ; Lagrosa Garcia, Sidney A ; Amira, Brenda V ; Rodrigues, Laura C ; Barreto, Mauricio L ; Rocha, Aline S ; de Cássia Ribeiro-Silva, Rita ; Falcão, Ila R ; Paixao, Enny S</creatorcontrib><description>SummaryBackgroundEarlier studies have proposed a link between the Interpregnancy Interval (IPI) and unfavorable birth outcomes. However, it remains unclear if the outcomes of previous births could affect this relationship. We aimed to investigate whether the occurrence of adverse outcomes–small for gestational age (SGA), preterm birth (PTB), and low birth weight (LBW)–at the immediately preceding pregnancy could alter the association between IPI and the same outcomes at the subsequent pregnancy. MethodsWe used a population-based linked cohort from Brazil (2001–2015). IPI was measured as the difference, in months, between the preceding birth and subsequent conception. Outcomes included SGA (&lt;10th birthweight percentile for gestational age and sex), LBW (&lt;2500 g), and PTB (gestational age &lt;37 weeks). We calculated risk ratios (RRs), using the IPI of 18–22 months as the reference IPI category, we also stratified by the number of adverse birth outcomes at the preceding pregnancy. FindingsAmong 4,788,279 births from 3,804,152 mothers, absolute risks for subsequent SGA, PTB, and LBW were higher for women with more adverse outcomes in the preceding delivery. The RR of SGA and LBW for IPIs &lt;6 months were greater for women without previous adverse outcomes (SGA: 1.44 [95% Confidence Interval (CI): 1.41–1.46]; LBW: 1.49 [1.45–1.52]) compared to those with three previous adverse outcomes (SGA: 1.20 [1.10–1.29]; LBW: 1.24 [1.15–1.33]). IPIs ≥120 months were associated with greater increases in risk for LBW and PTB among women without previous birth outcomes (LBW: 1.59; [1.53–1.65]; PTB: 2.45 [2.39–2.52]) compared to women with three adverse outcomes at the index birth (LBW: 0.92 [0.78–1.06]; PTB: 1.66 [1.44–1.88]). InterpretationOur study suggests that women with prior adverse outcomes may have higher risks for adverse birth outcomes in subsequent pregnancies. However, risk changes due to differences in IPI length seem to have a lesser impact compared to women without a prior event. Considering maternal obstetric history is essential in birth spacing counseling. FundingWellcome Trust225925/Z/22/Z.</description><identifier>ISSN: 2667-193X</identifier><identifier>EISSN: 2667-193X</identifier><identifier>DOI: 10.1016/j.lana.2024.100687</identifier><identifier>PMID: 38332936</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Birth spacing ; Internal Medicine ; Interpregnancy interval ; Low birth weight ; Perinatal outcomes ; Preterm ; Public Health ; Small-for-gestational-age</subject><ispartof>Lancet Regional Health - Americas (Online), 2024-02, Vol.30, p.100687-100687, Article 100687</ispartof><rights>The Author(s)</rights><rights>2024 The Author(s)</rights><rights>2024 The Author(s).</rights><rights>2024 The Author(s) 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c462t-efc9120e8cf9bc64fc321f715a381f3a943af321beb77a0c5025687bb8c91e203</cites><orcidid>0000-0002-4018-9501 ; 0000-0002-4797-908X ; 0000-0002-2526-5537</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10850771/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S2667193X24000140$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38332936$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tedde, João Guilherme G</creatorcontrib><creatorcontrib>Cerqueira-Silva, Thiago</creatorcontrib><creatorcontrib>Lagrosa Garcia, Sidney A</creatorcontrib><creatorcontrib>Amira, Brenda V</creatorcontrib><creatorcontrib>Rodrigues, Laura C</creatorcontrib><creatorcontrib>Barreto, Mauricio L</creatorcontrib><creatorcontrib>Rocha, Aline S</creatorcontrib><creatorcontrib>de Cássia Ribeiro-Silva, Rita</creatorcontrib><creatorcontrib>Falcão, Ila R</creatorcontrib><creatorcontrib>Paixao, Enny S</creatorcontrib><title>Association of interpregnancy interval with adverse pregnancy outcomes according to the outcomes of the preceding pregnancy: a longitudinal study with 4.7 million live births from Brazil</title><title>Lancet Regional Health - Americas (Online)</title><addtitle>Lancet Reg Health Am</addtitle><description>SummaryBackgroundEarlier studies have proposed a link between the Interpregnancy Interval (IPI) and unfavorable birth outcomes. However, it remains unclear if the outcomes of previous births could affect this relationship. We aimed to investigate whether the occurrence of adverse outcomes–small for gestational age (SGA), preterm birth (PTB), and low birth weight (LBW)–at the immediately preceding pregnancy could alter the association between IPI and the same outcomes at the subsequent pregnancy. MethodsWe used a population-based linked cohort from Brazil (2001–2015). IPI was measured as the difference, in months, between the preceding birth and subsequent conception. Outcomes included SGA (&lt;10th birthweight percentile for gestational age and sex), LBW (&lt;2500 g), and PTB (gestational age &lt;37 weeks). We calculated risk ratios (RRs), using the IPI of 18–22 months as the reference IPI category, we also stratified by the number of adverse birth outcomes at the preceding pregnancy. FindingsAmong 4,788,279 births from 3,804,152 mothers, absolute risks for subsequent SGA, PTB, and LBW were higher for women with more adverse outcomes in the preceding delivery. The RR of SGA and LBW for IPIs &lt;6 months were greater for women without previous adverse outcomes (SGA: 1.44 [95% Confidence Interval (CI): 1.41–1.46]; LBW: 1.49 [1.45–1.52]) compared to those with three previous adverse outcomes (SGA: 1.20 [1.10–1.29]; LBW: 1.24 [1.15–1.33]). IPIs ≥120 months were associated with greater increases in risk for LBW and PTB among women without previous birth outcomes (LBW: 1.59; [1.53–1.65]; PTB: 2.45 [2.39–2.52]) compared to women with three adverse outcomes at the index birth (LBW: 0.92 [0.78–1.06]; PTB: 1.66 [1.44–1.88]). InterpretationOur study suggests that women with prior adverse outcomes may have higher risks for adverse birth outcomes in subsequent pregnancies. However, risk changes due to differences in IPI length seem to have a lesser impact compared to women without a prior event. Considering maternal obstetric history is essential in birth spacing counseling. FundingWellcome Trust225925/Z/22/Z.</description><subject>Birth spacing</subject><subject>Internal Medicine</subject><subject>Interpregnancy interval</subject><subject>Low birth weight</subject><subject>Perinatal outcomes</subject><subject>Preterm</subject><subject>Public Health</subject><subject>Small-for-gestational-age</subject><issn>2667-193X</issn><issn>2667-193X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kstu1DAUhiMEolXpC7BAXrKZwZckjhECtRU3qRILQGJnOZ7jGQ-OPdjOoOHReDocUqaFBStfzv__x_J3quoxwUuCSftsu3TKqyXFtC4XuO34veqUti1fEMG-3L-zP6nOU9pijGnHGcPiYXXCOsaoYO1p9fMipaCtyjZ4FAyyPkPcRVh75fVhPu6VQ99t3iC12kNMgG7rYcw6DJCQ0jrElfVrlAPKG7itlNDpXDwafguO7udIIRf82uaxFEqTVDaHuVW95Giwzk3PcnYPqLcxbxIyMQzoMqof1j2qHhjlEpzfrGfV5zevP129W1x_ePv-6uJ6oeuW5gUYLQjF0Gkjet3WRjNKDCeNYh0xTImaKVOueug5V1g3mDblN_u-Kz6gmJ1Vr-bc3dgPsNLgc1RO7qIdVDzIoKz8u-LtRq7DXhLcNZhzUhKe3iTE8G2ElOVgkwZXCEIYk6SC1kI0ouVFSmepjiGlCObYh2A5gZdbOYGXE3g5gy-mJ3dfeLT8wVwEL2YBlH_aW4gyaQt-AlKwZLkK9v_5L_-xa2e91cp9hQOkbRhjwZckkYlKLD9OozdNHq3L1JEas1_lydoV</recordid><startdate>20240201</startdate><enddate>20240201</enddate><creator>Tedde, João Guilherme G</creator><creator>Cerqueira-Silva, Thiago</creator><creator>Lagrosa Garcia, Sidney A</creator><creator>Amira, Brenda V</creator><creator>Rodrigues, Laura C</creator><creator>Barreto, Mauricio L</creator><creator>Rocha, Aline S</creator><creator>de Cássia Ribeiro-Silva, Rita</creator><creator>Falcão, Ila R</creator><creator>Paixao, Enny S</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4018-9501</orcidid><orcidid>https://orcid.org/0000-0002-4797-908X</orcidid><orcidid>https://orcid.org/0000-0002-2526-5537</orcidid></search><sort><creationdate>20240201</creationdate><title>Association of interpregnancy interval with adverse pregnancy outcomes according to the outcomes of the preceding pregnancy: a longitudinal study with 4.7 million live births from Brazil</title><author>Tedde, João Guilherme G ; Cerqueira-Silva, Thiago ; Lagrosa Garcia, Sidney A ; Amira, Brenda V ; Rodrigues, Laura C ; Barreto, Mauricio L ; Rocha, Aline S ; de Cássia Ribeiro-Silva, Rita ; Falcão, Ila R ; Paixao, Enny S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-efc9120e8cf9bc64fc321f715a381f3a943af321beb77a0c5025687bb8c91e203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Birth spacing</topic><topic>Internal Medicine</topic><topic>Interpregnancy interval</topic><topic>Low birth weight</topic><topic>Perinatal outcomes</topic><topic>Preterm</topic><topic>Public Health</topic><topic>Small-for-gestational-age</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tedde, João Guilherme G</creatorcontrib><creatorcontrib>Cerqueira-Silva, Thiago</creatorcontrib><creatorcontrib>Lagrosa Garcia, Sidney A</creatorcontrib><creatorcontrib>Amira, Brenda V</creatorcontrib><creatorcontrib>Rodrigues, Laura C</creatorcontrib><creatorcontrib>Barreto, Mauricio L</creatorcontrib><creatorcontrib>Rocha, Aline S</creatorcontrib><creatorcontrib>de Cássia Ribeiro-Silva, Rita</creatorcontrib><creatorcontrib>Falcão, Ila R</creatorcontrib><creatorcontrib>Paixao, Enny S</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Lancet Regional Health - Americas (Online)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tedde, João Guilherme G</au><au>Cerqueira-Silva, Thiago</au><au>Lagrosa Garcia, Sidney A</au><au>Amira, Brenda V</au><au>Rodrigues, Laura C</au><au>Barreto, Mauricio L</au><au>Rocha, Aline S</au><au>de Cássia Ribeiro-Silva, Rita</au><au>Falcão, Ila R</au><au>Paixao, Enny S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of interpregnancy interval with adverse pregnancy outcomes according to the outcomes of the preceding pregnancy: a longitudinal study with 4.7 million live births from Brazil</atitle><jtitle>Lancet Regional Health - Americas (Online)</jtitle><addtitle>Lancet Reg Health Am</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>30</volume><spage>100687</spage><epage>100687</epage><pages>100687-100687</pages><artnum>100687</artnum><issn>2667-193X</issn><eissn>2667-193X</eissn><abstract>SummaryBackgroundEarlier studies have proposed a link between the Interpregnancy Interval (IPI) and unfavorable birth outcomes. However, it remains unclear if the outcomes of previous births could affect this relationship. We aimed to investigate whether the occurrence of adverse outcomes–small for gestational age (SGA), preterm birth (PTB), and low birth weight (LBW)–at the immediately preceding pregnancy could alter the association between IPI and the same outcomes at the subsequent pregnancy. MethodsWe used a population-based linked cohort from Brazil (2001–2015). IPI was measured as the difference, in months, between the preceding birth and subsequent conception. Outcomes included SGA (&lt;10th birthweight percentile for gestational age and sex), LBW (&lt;2500 g), and PTB (gestational age &lt;37 weeks). We calculated risk ratios (RRs), using the IPI of 18–22 months as the reference IPI category, we also stratified by the number of adverse birth outcomes at the preceding pregnancy. FindingsAmong 4,788,279 births from 3,804,152 mothers, absolute risks for subsequent SGA, PTB, and LBW were higher for women with more adverse outcomes in the preceding delivery. The RR of SGA and LBW for IPIs &lt;6 months were greater for women without previous adverse outcomes (SGA: 1.44 [95% Confidence Interval (CI): 1.41–1.46]; LBW: 1.49 [1.45–1.52]) compared to those with three previous adverse outcomes (SGA: 1.20 [1.10–1.29]; LBW: 1.24 [1.15–1.33]). IPIs ≥120 months were associated with greater increases in risk for LBW and PTB among women without previous birth outcomes (LBW: 1.59; [1.53–1.65]; PTB: 2.45 [2.39–2.52]) compared to women with three adverse outcomes at the index birth (LBW: 0.92 [0.78–1.06]; PTB: 1.66 [1.44–1.88]). InterpretationOur study suggests that women with prior adverse outcomes may have higher risks for adverse birth outcomes in subsequent pregnancies. However, risk changes due to differences in IPI length seem to have a lesser impact compared to women without a prior event. Considering maternal obstetric history is essential in birth spacing counseling. FundingWellcome Trust225925/Z/22/Z.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>38332936</pmid><doi>10.1016/j.lana.2024.100687</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-4018-9501</orcidid><orcidid>https://orcid.org/0000-0002-4797-908X</orcidid><orcidid>https://orcid.org/0000-0002-2526-5537</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2667-193X
ispartof Lancet Regional Health - Americas (Online), 2024-02, Vol.30, p.100687-100687, Article 100687
issn 2667-193X
2667-193X
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10850771
source Elsevier ScienceDirect Journals; PubMed Central
subjects Birth spacing
Internal Medicine
Interpregnancy interval
Low birth weight
Perinatal outcomes
Preterm
Public Health
Small-for-gestational-age
title Association of interpregnancy interval with adverse pregnancy outcomes according to the outcomes of the preceding pregnancy: a longitudinal study with 4.7 million live births from Brazil
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-03-07T02%3A58%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20interpregnancy%20interval%20with%20adverse%20pregnancy%20outcomes%20according%20to%20the%20outcomes%20of%20the%20preceding%20pregnancy:%20a%20longitudinal%20study%20with%204.7%20million%20live%20births%20from%20Brazil&rft.jtitle=Lancet%20Regional%20Health%20-%20Americas%20(Online)&rft.au=Tedde,%20Jo%C3%A3o%20Guilherme%20G&rft.date=2024-02-01&rft.volume=30&rft.spage=100687&rft.epage=100687&rft.pages=100687-100687&rft.artnum=100687&rft.issn=2667-193X&rft.eissn=2667-193X&rft_id=info:doi/10.1016/j.lana.2024.100687&rft_dat=%3Cproquest_pubme%3E2924995967%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c462t-efc9120e8cf9bc64fc321f715a381f3a943af321beb77a0c5025687bb8c91e203%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2924995967&rft_id=info:pmid/38332936&rfr_iscdi=true