Use of Potentially Inappropriate Medications in People With Dementia in Vietnam and Its Associated Factors

This study examined the use of potentially inappropriate medicines that may affect cognition (PIMcog) in people with dementia and its associated factors. Medical records of all outpatients with dementia attending a tertiary hospital in Vietnam between January 1, 2015, and December 31, 2016, were exa...

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Bibliographic Details
Published in:American journal of Alzheimer's disease and other dementias 2018-11, Vol.33 (7), p.423-432
Main Authors: Nguyen, Tuan Anh, Pham, Thang, Vu, Huyen Thi Thanh, Nguyen, Thanh Xuan, Vu, Trinh Thi, Nguyen, Binh Thi Thanh, Nguyen, Ngoc Quynh, Nguyen, Binh Thanh, Nguyen, Tam Ngoc, Phan, Sinh Viet, Nguyen, Anh Trung, Pham, Tuan Le, Dang, Ha Thu, Kalisch-Ellett, Lisa, Gillam, Marianne, Pratt, Nicole, Qiang, Sun, Wang, Haipeng, Kanjanarach, Tipaporn, Hassali, Mohamed Azmi Ahmad, Babar, Zaheer-Ud-Din, Razak, Asrenee Ab, Chinwong, Dujrudee, Roughead, Elizabeth E.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antipsychotic Agents - administration & dosage
Antipsychotic Agents - adverse effects
Cholinergic Antagonists - administration & dosage
Cholinergic Antagonists - adverse effects
Cholinesterase Inhibitors - administration & dosage
Cholinesterase Inhibitors - adverse effects
Cognition - drug effects
Current Topics in Management
Dementia - epidemiology
Female
Humans
Male
Potentially Inappropriate Medication List - standards
Vietnam - epidemiology
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Summary:This study examined the use of potentially inappropriate medicines that may affect cognition (PIMcog) in people with dementia and its associated factors. Medical records of all outpatients with dementia attending a tertiary hospital in Vietnam between January 1, 2015, and December 31, 2016, were examined. Medicine use was assessed against a list of PIMcog. Variables associated with having a PIMcog were assessed using a multiple logistic regression. Of the 128 patients, 41% used a PIMcog, 39.1% used cholinesterase inhibitors (CEIs) concomitantly with anticholinergics, and 18% used antipsychotics. The number of hospital visits (adjusted odds ratio [OR]: 1.08; 95% confidence interval [CI]: 1.02-1.16) and number of treating specialists (adjusted OR: 0.61; 95% CI: 0.45-0.83) were associated with PIMcog use. This study highlights a high-level use of medicines that can further impair cognition or reduce the effectiveness of CEIs in people with dementia. Efforts to improve quality use of medicines for this population are warranted.
ISSN:1533-3175
1938-2731
1938-2731
DOI:10.1177/1533317518768999