Association of Alzheimer's Disease With APOE and IL-1α Gene Polymorphisms

• Published in: American journal of Alzheimer's disease and other dementias 2015-12, Vol.30 (8), p.756-761
• Main Authors: Yildiz, Saliha Handan, Erdogan, Mujgan Ozdemir, Artan, Sevilhan, Solak, Mustafa, Yaman, Mehmet, Ozbabalik, Belgin Demet, Terzi, Evrim Suna Arikan
• Format: Article
• Language: English
• Subjects: Aged; Alzheimer Disease - genetics; Apolipoprotein E2 - genetics; Apolipoprotein E3 - genetics; Apolipoprotein E4 - genetics; Humans; Interleukin-1alpha - genetics; Polymorphism, Genetic; Turkey
• ISSN: 1533-3175; 1938-2731
• DOI: 10.1177/1533317512461557

Apolipoprotein E (ApoE) gene polymorphisms are thought to be the most important genetic risk factor in the pathogenesis of late onset and sporadic Alzheimer’s disease (AD). Moreover, interleukin-1α (IL-1α) is found to be associated with the pathogenesis of AD. In this research, ∊2, ∊3, and ∊4 polymorphisms of ApoE gene and C889T polymorphism of IL-1α gene were genotyped in patients with AD and controls. Genotyping was performed by real-time polymerase chain reaction. ∊3/∊3 and ∊3/∊4 genotype frequencies were significantly higher in control and case groups, respectively. While ∊3 allele frequencies were significantly higher in the control group, ∊2 and ∊4 allele frequencies were significantly higher among the cases with AD. No difference was found between the groups according to C889T polymorphism of IL-1α. In conclusion, we demonstrated that there was a strong association between ApoE ∊4 allele and AD, while there was no relation with IL-1α C889T polymorphisms for this study.