Predicting Severity in Hypertriglyceridemia-Induced Acute Pancreatitis: The Role of Neutrophils, Calcium, and Apolipoproteins

• Published in: Medical science monitor 2024-02, Vol.30, p.e942832-e942832
• Main Authors: Hu, Ying-Qiu, Tao, Xia, Wu, Hai-Bo, Li, Wu-Gen, Chen, Ding-Yi, Liu, Yuan-Fei, Tao, Shao-Yu, Wang, Kai-Yang
• Format: Article
• Language: English
• Subjects: Acute Disease; Apolipoproteins; Apolipoproteins A; Apolipoproteins B; Calcium; Clinical Research; Humans; Hypertriglyceridemia - complications; Neutrophils; Pancreatitis; Retrospective Studies
• ISSN: 1643-3750; 1234-1010; 1643-3750
• DOI: 10.12659/MSM.942832

BACKGROUND Hypertriglyceridemia-induced acute pancreatitis (HTG-AP), representing 10% of all acute pancreatitis cases, is characterized by younger onset age and more severe progression, often leading to higher ICU admission rates. This condition poses a significant challenge due to its rapid progression and the potential for severe complications, including multiple organ failure. HTG-AP is distinct from other forms of pancreatitis, such as those caused by cholelithiasis or alcohol, in terms of clinical presentation and outcomes. It's essential to identify early markers that can predict the severity of HTG-AP to improve patient management and outcomes. MATERIAL AND METHODS This study divided 127 HTG-AP patients into mild acute pancreatitis (MAP, n=71) and moderate-to-severe acute pancreatitis (MSAP/SAP, n=56) groups. Blood biological indicators within the first 24 hours of admission were analyzed. Risk factors for HTG-AP progression were determined using binary logistic regression and ROC curves. RESULTS Elevated levels of HCT, NLR, TBI, DBI, AST, Cre, and AMS were noted in the MSAP/SAP group, with lower levels of LYM, Na⁺, Ca²⁺, ApoA, and ApoB compared to the MAP group (p