Relationship between hepatic surgical margins of colorectal cancer liver metastases and prognosis: A review

Colorectal cancer (CRC) remains a significant global health concern, as characterized by its high mortality rate ranking second among all the leading causes of death. The liver serves as the primary site of CRC metastasis, and the occurrence of liver metastasis is a significant contributor to mortal...

Full description

Saved in:
Bibliographic Details
Published in:Medicine (Baltimore) 2024-02, Vol.103 (6), p.e37038
Main Authors: Ai, Xiang-Nan, Zhang, Qiang, Jin, Chang-Guo, Hu, Hao, Zhang, Wen-Xuan, Wu, Zhen-Yu, Xiu, Dian-Rong
Format: Article
Language:English
Subjects:
Narrative Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Colorectal cancer (CRC) remains a significant global health concern, as characterized by its high mortality rate ranking second among all the leading causes of death. The liver serves as the primary site of CRC metastasis, and the occurrence of liver metastasis is a significant contributor to mortality among patients diagnosed with CRC. The survival rate of patients with colorectal liver metastasis has significantly increased with the advancement of comprehensive tumor therapy. However, radical surgery remains the key factor. Since there are frequently multiple liver metastases, which are prone to recurrence after surgery, it is crucial to preserve as much liver parenchyma as possible without affecting the prognosis. The issue of surgical margins plays a crucial role in this regard. In this review, we begin by examining the occurrence of positive surgical margins in liver metastases of patients diagnosed with CRC. We aim to define positive margins in hepatic surgery, examine the relationship between margins and prognosis and establish a foundation for future research in this field.
ISSN:0025-7974
1536-5964
1536-5964
DOI:10.1097/MD.0000000000037038