Recovery after Prolonged Disturbance of Consciousness and Repeated Cerebral Perfusion Changes in Neuronal Intranuclear Inclusion Disease

Encephalitic episodes are a clinical manifestation of neuronal intranuclear inclusion disease (NIID) and often show transient disturbance of consciousness. We herein report a genetically confirmed patient with NIID who initially presented progressive dementia and showed prolonged disturbance of cons...

Full description

Saved in:
Bibliographic Details
Published in:Internal Medicine 2024/01/15, Vol.63(2), pp.333-336
Main Authors: Uchigami, Hirokazu, Hamada, Masashi, Maekawa, Hirotaka, Ishiura, Hiroyuki, Kodama, Satoshi, Shirota, Yuichiro, Takahashi, Miwako, Momose, Toshimitsu, Toda, Tatsushi
Format: Article
Language:English
Subjects:
Blood flow
Case Report
Cerebrovascular Circulation
Computed tomography
Consciousness
Dementia - complications
Dementia disorders
disturbance of consciousness
encephalitic episode
Encephalitis - complications
Humans
Intranuclear Inclusion Bodies
Neurodegenerative Diseases - complications
Neurodegenerative Diseases - diagnostic imaging
neuronal intranuclear inclusion disease
single-photon emission computed tomography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c643t-12952d0dfefa7ef6fb2574290b05533a33a1b7b07033bc5e75152f126cca9bf73
cites cdi_FETCH-LOGICAL-c643t-12952d0dfefa7ef6fb2574290b05533a33a1b7b07033bc5e75152f126cca9bf73
container_end_page 336
container_issue 2
container_start_page 333
container_title Internal Medicine
container_volume 63
creator Uchigami, Hirokazu
Hamada, Masashi
Maekawa, Hirotaka
Ishiura, Hiroyuki
Kodama, Satoshi
Shirota, Yuichiro
Takahashi, Miwako
Momose, Toshimitsu
Toda, Tatsushi
description Encephalitic episodes are a clinical manifestation of neuronal intranuclear inclusion disease (NIID) and often show transient disturbance of consciousness. We herein report a genetically confirmed patient with NIID who initially presented progressive dementia and showed prolonged disturbance of consciousness preceded by an acute-onset headache. During that time, we performed N-isopropyl-p-[123I] iodoamphetamine single-photon-emission computed tomography twice and found that the blood flow increased in different regions. Prolonged disturbance of consciousness following an encephalitic episode may be associated with repeated hyperperfusion in various regions resulting from mitochondrial dysfunction. NIID patients presenting with encephalitic episodes can recover gradually and spontaneously even after prolonged disturbances of consciousness.
doi_str_mv 10.2169/internalmedicine.1015-22
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10864064</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2821642427</sourcerecordid><originalsourceid>FETCH-LOGICAL-c643t-12952d0dfefa7ef6fb2574290b05533a33a1b7b07033bc5e75152f126cca9bf73</originalsourceid><addsrcrecordid>eNplkV2LEzEUhoMobq3-BQl4482s-ZhMZq5E6tfCsi6LXocz6UmbMk1qMrOw_8CfbYbWoiuEE0KevOfNeQmhnF0K3nTvfBgxBRj2uPbWB7zkjKtKiCdkwWXdVVpI9ZQsWMfbSpRyQV7kvGNMtroTz8mF1EK1XLMF-XWHNt5jeqDgiia9TXGIYYNr-tHncUo9BIs0OrqKIVsfpxwwZwphTe_wgDAWcoUJ-wQDvcXkpuxjoKstFJFMfaA3OKVYvNKrMCYIkx0QUjnY4YiWPggZX5JnDoaMr077kvz4_On76mt1_e3L1erDdWWbWo4VF50Sa7Z26ECja1wvlK5Fx3qmlJRQFu91zzSTsrcKteJKOC4aa6HrnZZL8v6oe5j6Mj6Ls6vBHJLfQ3owEbz59yb4rdnEe8NZ29SsmFiStyeFFH9OmEez99niMEDAMh8j2pJRLWoxN3vzCN3FaQ6uUJ1oZKNVPQu2R8qmmHNCd3bDmZnzNo_zNnPeRojy9PXfvzk__BNwAW6OwC6PsMEzAGn0JYn_lRtpxFxOHc6g3UIyGORviEfMaA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2926367544</pqid></control><display><type>article</type><title>Recovery after Prolonged Disturbance of Consciousness and Repeated Cerebral Perfusion Changes in Neuronal Intranuclear Inclusion Disease</title><source>PubMed Central</source><creator>Uchigami, Hirokazu ; Hamada, Masashi ; Maekawa, Hirotaka ; Ishiura, Hiroyuki ; Kodama, Satoshi ; Shirota, Yuichiro ; Takahashi, Miwako ; Momose, Toshimitsu ; Toda, Tatsushi</creator><creatorcontrib>Uchigami, Hirokazu ; Hamada, Masashi ; Maekawa, Hirotaka ; Ishiura, Hiroyuki ; Kodama, Satoshi ; Shirota, Yuichiro ; Takahashi, Miwako ; Momose, Toshimitsu ; Toda, Tatsushi</creatorcontrib><description>Encephalitic episodes are a clinical manifestation of neuronal intranuclear inclusion disease (NIID) and often show transient disturbance of consciousness. We herein report a genetically confirmed patient with NIID who initially presented progressive dementia and showed prolonged disturbance of consciousness preceded by an acute-onset headache. During that time, we performed N-isopropyl-p-[123I] iodoamphetamine single-photon-emission computed tomography twice and found that the blood flow increased in different regions. Prolonged disturbance of consciousness following an encephalitic episode may be associated with repeated hyperperfusion in various regions resulting from mitochondrial dysfunction. NIID patients presenting with encephalitic episodes can recover gradually and spontaneously even after prolonged disturbances of consciousness.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.1015-22</identifier><identifier>PMID: 37258170</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Blood flow ; Case Report ; Cerebrovascular Circulation ; Computed tomography ; Consciousness ; Dementia - complications ; Dementia disorders ; disturbance of consciousness ; encephalitic episode ; Encephalitis - complications ; Humans ; Intranuclear Inclusion Bodies ; Neurodegenerative Diseases - complications ; Neurodegenerative Diseases - diagnostic imaging ; neuronal intranuclear inclusion disease ; single-photon emission computed tomography</subject><ispartof>Internal Medicine, 2024/01/15, Vol.63(2), pp.333-336</ispartof><rights>2024 by The Japanese Society of Internal Medicine</rights><rights>2024. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2024 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c643t-12952d0dfefa7ef6fb2574290b05533a33a1b7b07033bc5e75152f126cca9bf73</citedby><cites>FETCH-LOGICAL-c643t-12952d0dfefa7ef6fb2574290b05533a33a1b7b07033bc5e75152f126cca9bf73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864064/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864064/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37258170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uchigami, Hirokazu</creatorcontrib><creatorcontrib>Hamada, Masashi</creatorcontrib><creatorcontrib>Maekawa, Hirotaka</creatorcontrib><creatorcontrib>Ishiura, Hiroyuki</creatorcontrib><creatorcontrib>Kodama, Satoshi</creatorcontrib><creatorcontrib>Shirota, Yuichiro</creatorcontrib><creatorcontrib>Takahashi, Miwako</creatorcontrib><creatorcontrib>Momose, Toshimitsu</creatorcontrib><creatorcontrib>Toda, Tatsushi</creatorcontrib><title>Recovery after Prolonged Disturbance of Consciousness and Repeated Cerebral Perfusion Changes in Neuronal Intranuclear Inclusion Disease</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Encephalitic episodes are a clinical manifestation of neuronal intranuclear inclusion disease (NIID) and often show transient disturbance of consciousness. We herein report a genetically confirmed patient with NIID who initially presented progressive dementia and showed prolonged disturbance of consciousness preceded by an acute-onset headache. During that time, we performed N-isopropyl-p-[123I] iodoamphetamine single-photon-emission computed tomography twice and found that the blood flow increased in different regions. Prolonged disturbance of consciousness following an encephalitic episode may be associated with repeated hyperperfusion in various regions resulting from mitochondrial dysfunction. NIID patients presenting with encephalitic episodes can recover gradually and spontaneously even after prolonged disturbances of consciousness.</description><subject>Blood flow</subject><subject>Case Report</subject><subject>Cerebrovascular Circulation</subject><subject>Computed tomography</subject><subject>Consciousness</subject><subject>Dementia - complications</subject><subject>Dementia disorders</subject><subject>disturbance of consciousness</subject><subject>encephalitic episode</subject><subject>Encephalitis - complications</subject><subject>Humans</subject><subject>Intranuclear Inclusion Bodies</subject><subject>Neurodegenerative Diseases - complications</subject><subject>Neurodegenerative Diseases - diagnostic imaging</subject><subject>neuronal intranuclear inclusion disease</subject><subject>single-photon emission computed tomography</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNplkV2LEzEUhoMobq3-BQl4482s-ZhMZq5E6tfCsi6LXocz6UmbMk1qMrOw_8CfbYbWoiuEE0KevOfNeQmhnF0K3nTvfBgxBRj2uPbWB7zkjKtKiCdkwWXdVVpI9ZQsWMfbSpRyQV7kvGNMtroTz8mF1EK1XLMF-XWHNt5jeqDgiia9TXGIYYNr-tHncUo9BIs0OrqKIVsfpxwwZwphTe_wgDAWcoUJ-wQDvcXkpuxjoKstFJFMfaA3OKVYvNKrMCYIkx0QUjnY4YiWPggZX5JnDoaMr077kvz4_On76mt1_e3L1erDdWWbWo4VF50Sa7Z26ECja1wvlK5Fx3qmlJRQFu91zzSTsrcKteJKOC4aa6HrnZZL8v6oe5j6Mj6Ls6vBHJLfQ3owEbz59yb4rdnEe8NZ29SsmFiStyeFFH9OmEez99niMEDAMh8j2pJRLWoxN3vzCN3FaQ6uUJ1oZKNVPQu2R8qmmHNCd3bDmZnzNo_zNnPeRojy9PXfvzk__BNwAW6OwC6PsMEzAGn0JYn_lRtpxFxOHc6g3UIyGORviEfMaA</recordid><startdate>20240115</startdate><enddate>20240115</enddate><creator>Uchigami, Hirokazu</creator><creator>Hamada, Masashi</creator><creator>Maekawa, Hirotaka</creator><creator>Ishiura, Hiroyuki</creator><creator>Kodama, Satoshi</creator><creator>Shirota, Yuichiro</creator><creator>Takahashi, Miwako</creator><creator>Momose, Toshimitsu</creator><creator>Toda, Tatsushi</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240115</creationdate><title>Recovery after Prolonged Disturbance of Consciousness and Repeated Cerebral Perfusion Changes in Neuronal Intranuclear Inclusion Disease</title><author>Uchigami, Hirokazu ; Hamada, Masashi ; Maekawa, Hirotaka ; Ishiura, Hiroyuki ; Kodama, Satoshi ; Shirota, Yuichiro ; Takahashi, Miwako ; Momose, Toshimitsu ; Toda, Tatsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c643t-12952d0dfefa7ef6fb2574290b05533a33a1b7b07033bc5e75152f126cca9bf73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Blood flow</topic><topic>Case Report</topic><topic>Cerebrovascular Circulation</topic><topic>Computed tomography</topic><topic>Consciousness</topic><topic>Dementia - complications</topic><topic>Dementia disorders</topic><topic>disturbance of consciousness</topic><topic>encephalitic episode</topic><topic>Encephalitis - complications</topic><topic>Humans</topic><topic>Intranuclear Inclusion Bodies</topic><topic>Neurodegenerative Diseases - complications</topic><topic>Neurodegenerative Diseases - diagnostic imaging</topic><topic>neuronal intranuclear inclusion disease</topic><topic>single-photon emission computed tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uchigami, Hirokazu</creatorcontrib><creatorcontrib>Hamada, Masashi</creatorcontrib><creatorcontrib>Maekawa, Hirotaka</creatorcontrib><creatorcontrib>Ishiura, Hiroyuki</creatorcontrib><creatorcontrib>Kodama, Satoshi</creatorcontrib><creatorcontrib>Shirota, Yuichiro</creatorcontrib><creatorcontrib>Takahashi, Miwako</creatorcontrib><creatorcontrib>Momose, Toshimitsu</creatorcontrib><creatorcontrib>Toda, Tatsushi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uchigami, Hirokazu</au><au>Hamada, Masashi</au><au>Maekawa, Hirotaka</au><au>Ishiura, Hiroyuki</au><au>Kodama, Satoshi</au><au>Shirota, Yuichiro</au><au>Takahashi, Miwako</au><au>Momose, Toshimitsu</au><au>Toda, Tatsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recovery after Prolonged Disturbance of Consciousness and Repeated Cerebral Perfusion Changes in Neuronal Intranuclear Inclusion Disease</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2024-01-15</date><risdate>2024</risdate><volume>63</volume><issue>2</issue><spage>333</spage><epage>336</epage><pages>333-336</pages><artnum>1015-22</artnum><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Encephalitic episodes are a clinical manifestation of neuronal intranuclear inclusion disease (NIID) and often show transient disturbance of consciousness. We herein report a genetically confirmed patient with NIID who initially presented progressive dementia and showed prolonged disturbance of consciousness preceded by an acute-onset headache. During that time, we performed N-isopropyl-p-[123I] iodoamphetamine single-photon-emission computed tomography twice and found that the blood flow increased in different regions. Prolonged disturbance of consciousness following an encephalitic episode may be associated with repeated hyperperfusion in various regions resulting from mitochondrial dysfunction. NIID patients presenting with encephalitic episodes can recover gradually and spontaneously even after prolonged disturbances of consciousness.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>37258170</pmid><doi>10.2169/internalmedicine.1015-22</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0918-2918
ispartof Internal Medicine, 2024/01/15, Vol.63(2), pp.333-336
issn 0918-2918
1349-7235
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10864064
source PubMed Central
subjects Blood flow
Case Report
Cerebrovascular Circulation
Computed tomography
Consciousness
Dementia - complications
Dementia disorders
disturbance of consciousness
encephalitic episode
Encephalitis - complications
Humans
Intranuclear Inclusion Bodies
Neurodegenerative Diseases - complications
Neurodegenerative Diseases - diagnostic imaging
neuronal intranuclear inclusion disease
single-photon emission computed tomography
title Recovery after Prolonged Disturbance of Consciousness and Repeated Cerebral Perfusion Changes in Neuronal Intranuclear Inclusion Disease
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T12%3A20%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Recovery%20after%20Prolonged%20Disturbance%20of%20Consciousness%20and%20Repeated%20Cerebral%20Perfusion%20Changes%20in%20Neuronal%20Intranuclear%20Inclusion%20Disease&rft.jtitle=Internal%20Medicine&rft.au=Uchigami,%20Hirokazu&rft.date=2024-01-15&rft.volume=63&rft.issue=2&rft.spage=333&rft.epage=336&rft.pages=333-336&rft.artnum=1015-22&rft.issn=0918-2918&rft.eissn=1349-7235&rft_id=info:doi/10.2169/internalmedicine.1015-22&rft_dat=%3Cproquest_pubme%3E2821642427%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c643t-12952d0dfefa7ef6fb2574290b05533a33a1b7b07033bc5e75152f126cca9bf73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2926367544&rft_id=info:pmid/37258170&rfr_iscdi=true