Reply to Martinez-Garcia et al. and to Wang et al

Allinson et al respond to comments on their article on long-term doxycycline therapy for stable chronic obstructive pulmonary disease. They state that by design, they enriched their study sample for those with histories of exacerbations, and infection is recognized as a major cause of such exacerbat...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2023-11, Vol.208 (10), p.1144-1145
Main Authors: Allinson, James P, Vlies, Ben H, Brill, Simon E, Law, Martin, Burnside, Girvan, Finney, Lydia J, Alves-Moreira, Luana, Calverley, Peter M A, Walker, Paul P, Wedzicha, Jadwiga A
Format: Article
Language:English
Subjects:
Chronic obstructive pulmonary disease
Correspondence
Drug therapy
Lung diseases
Medical research
Research methodology
Citations: Items that this one cites
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Summary:Allinson et al respond to comments on their article on long-term doxycycline therapy for stable chronic obstructive pulmonary disease. They state that by design, they enriched their study sample for those with histories of exacerbations, and infection is recognized as a major cause of such exacerbations. Therefore, the bacteriostatic action of doxycycline is a probable mechanism of action, as they discuss. Delineating the mechanism responsible is important. Microbial analyses of sputum collected during this clinical trial were not a prespecified trial outcome, so they were not reported as such. Sputum samples were not available from all study participants, but the available samples are the subject of their ongoing research.
ISSN:1073-449X
1535-4970
1535-4970
DOI:10.1164/rccm.202309-1604LE