The Counter Effect of Exercise on Cisplatin-Induced Cognitive and Proliferation Impairments

Background Cisplatin, a widely used chemotherapeutic agent, offers therapeutic benefits for cancer treatment but often leads to adverse effects on neurogenesis and oxidative stress, causing cognitive impairment. Concurrent physical activity has been proposed as a potential strategy to counteract the...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2024-01, Vol.16 (1), p.e52526-e52526
Main Authors: Elbeltagy, Maha, Al-Horani, Ramzi A, Alsharaeh, Tala S, Alkhatib, Amro H, Alawaisheh, Ibrahim, Abuhani, Ahmad A, Salman, Ahmed
Format: Article
Language:English
Subjects:
Animal cognition
Antibodies
Cancer therapies
Cognitive ability
Drug dosages
Exercise
Fitness equipment
Fitness training programs
Food
Mitochondrial DNA
Neurogenesis
Neurology
Oxidative stress
Physical fitness
Quality of life
Radiation
Software
Variance analysis
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Summary:Background Cisplatin, a widely used chemotherapeutic agent, offers therapeutic benefits for cancer treatment but often leads to adverse effects on neurogenesis and oxidative stress, causing cognitive impairment. Concurrent physical activity has been proposed as a potential strategy to counteract these side effects. This study aimed to investigate the impact of physical exercise on cisplatin-induced cognitive impairment in a mouse model. Methods Adult male mice (n=45) were divided into three groups: control, cisplatin-treated (2.3 mg/kg), and exercise/cisplatin. Cisplatin was administered intraperitoneally over one month, while the exercise/cisplatin group underwent moderate-intensity exercise alongside cisplatin treatment. Spatial memory was evaluated using the novel object recognition (NOR) task, and hippocampal proliferation and oxidative stress were examined using Ki-67 and glutathione peroxidase (GPx) immunohistochemistry (IHC) staining, respectively. Statistical analyses were performed using the GraphPad Prism 4.0 software (GraphPad Software, San Diego, CA). Results The cisplatin-treated mice exhibited significantly lower preference index (PI) scores in the NOR task compared to the control (p
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.52526