Characteristics of the Symptoms of the Proposed ND-PAE Disorder in First Grade Children in a Community Sample

The proposed symptoms for Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE) were evaluated in children who participated in the Collaboration on Fetal Alcohol Spectrum Disorders Prevalence study. Children “at-risk” for ND-PAE (n = 204) were contrasted to children with no pre...

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Bibliographic Details
Published in:Child psychiatry and human development 2024-04, Vol.55 (2), p.426-438
Main Authors: Kable, Julie A., Coles, Claire D., Holton, Jennifer E., Kalberg, Wendy O., May, Philip A., Chambers, Christina D., Bandoli, Gretchen
Format: Article
Language:English
Subjects:
Behavioral Science and Psychology
Child & adolescent psychiatry
Child and School Psychology
Children
Children & youth
Cognition
Cognition & reasoning
Collaboration
Diagnosis
Discrimination
Drug abuse
Fetal alcohol syndrome
Intelligence
Intelligence tests
Internal validity
Measuring techniques
Medical diagnosis
Mental disorders
Mental health
Neurobehavioral functioning
Original Article
Predictive validity
Prenatal care
Prenatal experience
Prenatal exposure
Psychiatry
Psychology
Self regulation
Sexually transmitted diseases
STD
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Summary:The proposed symptoms for Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE) were evaluated in children who participated in the Collaboration on Fetal Alcohol Spectrum Disorders Prevalence study. Children “at-risk” for ND-PAE (n = 204) were contrasted to children with no prenatal alcohol exposure, alcohol-related dysmorphia or growth deficits (n = 908). Symptoms were defined based on neuropsychological testing using two diagnostic threshold levels (1.0 and 1.5 STD). Individuals at risk for ND-PAE had higher endorsement rates of the self-regulation and adaptive impairments at the 1.0 threshold and of the neurocognitive and self-regulation impairments at the 1.5 threshold. Endorsement of the disorder significantly differed at the 1.0 threshold. Receiver operating characteristic curve analysis indicated that having an IQ below 70 was not predictive of the diagnosis but modifications of the IQ criterion improved predictive validity. Discrimination validity was poor without documentation of PAE which continues to be a necessity for a diagnosis of ND-PAE.
ISSN:0009-398X
1573-3327
DOI:10.1007/s10578-022-01414-8