The causal relationship between psoriasis and chronic obstructive pulmonary disease: A bidirectional mendelian randomization study

Purpose Although many studies have investigated the association between psoriasis and chronic obstructive pulmonary disease (COPD), the causal relationship between psoriasis and COPD is still unknown. Methods We employed bidirectional Mendelian randomization to investigate the causal relationship be...

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Bibliographic Details
Published in:Skin research and technology 2024-03, Vol.30 (3), p.e13629-n/a
Main Authors: Liu, Meng, Zhou, Xiaolin, Zhang, Guanfei, Liu, Luyu, Fang, Chengyu, Li, Ziyan, Zheng, Yan
Format: Article
Language:English
Subjects:
causality
Chronic obstructive pulmonary disease
COPD
Genome-Wide Association Study
Genomes
Heterogeneity
Humans
Linkage disequilibrium
Lung diseases
mendelian randomization
Mendelian Randomization Analysis
Nucleotides
Original
Pleiotropy
Psoriasis
Psoriasis - epidemiology
Psoriasis - genetics
Pulmonary Disease, Chronic Obstructive - epidemiology
Pulmonary Disease, Chronic Obstructive - genetics
Randomization
Reproducibility of Results
Robustness (mathematics)
Single-nucleotide polymorphism
Skin diseases
Statistical analysis
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Summary:Purpose Although many studies have investigated the association between psoriasis and chronic obstructive pulmonary disease (COPD), the causal relationship between psoriasis and COPD is still unknown. Methods We employed bidirectional Mendelian randomization to investigate the causal relationship between psoriasis and COPD. Genetic instruments for exposure were selected from two distinct genome‐wide association study databases. Single nucleotide polymorphisms associated with exposures at the genome‐wide significance level (p 
ISSN:0909-752X
1600-0846
1600-0846
DOI:10.1111/srt.13629