A Rare Presentation of Wegener's Granulomatosis With Perinuclear Antineutrophil Cytoplasmic Antibody Positivity

Wegener's granulomatosis (WG), also termed granulomatosis with polyangiitis, is a vasculitic condition with numerous systemic manifestations. It is mainly a pauci-immune vasculitis which involves small and medium-sized vessels. Herein, we report a case of a 72-year-old female with a background...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2024-01, Vol.16 (1), p.e53078
Main Authors: Rathnayake, Dhammika P, Janaka, Kvc, Hussain, Hassan, Senanayake, Sudeshan, Lakindi, Wds
Format: Article
Language:English
Subjects:
Allergy/Immunology
Anemia
Antibodies
Biopsy
Case reports
Chronic illnesses
Disease
Fever
Hemoglobin
Hemoptysis
Inflammation
Inflammatory diseases
Internal Medicine
Lungs
Neutrophils
Rheumatology
Sinusitis
Tomography
Vein & artery diseases
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Summary:Wegener's granulomatosis (WG), also termed granulomatosis with polyangiitis, is a vasculitic condition with numerous systemic manifestations. It is mainly a pauci-immune vasculitis which involves small and medium-sized vessels. Herein, we report a case of a 72-year-old female with a background history of type 2 diabetes mellitus and hypertension. She presented to the hospital with recurrent nasal congestion, headache, and intermittent facial pain for two months' duration. At the initial presentation, she was diagnosed with pansinusitis, for which she was treated with antibiotics and was discharged. Two weeks later, she presented with progressively worsening bilateral lower limb numbness and weakness for one week's duration. With serial investigations, she was diagnosed with WG and was treated with intravenous methylprednisolone along with cyclophosphamide, after which she made a significant improvement in her clinical status.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.53078