Human orf virus (family Poxviridae) infection following a lamb bite in Hungary

Human orf disease (called ecthyma contagiosum or contagious/infectious pustular dermatitis in animals) was confirmed on the fingers of both hands of a 24-year-old female, after feeding diseased lambs with a nursing bottle in April 2023. In addition to skin symptoms, she had low-grade fever (37.6°C)...

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Bibliographic Details
Published in:Archives of virology 2024-03, Vol.169 (3), p.59-59, Article 59
Main Authors: Németh, Csongor, Boros, Ákos, Mészáros, Endre, Gyömörei, Csaba, Albert, Ervin, Pankovics, Péter, Reuter, Gábor
Format: Article
Language:English
Subjects:
Adult
Animals
Biomedical and Life Sciences
Biomedicine
Biopsy
Brief Report
Dermatitis
Dermatology
Disease
DNA, Viral - genetics
Ecthyma
Ecthyma, Contagious - epidemiology
Female
Genomes
Humans
Hungary
Infections
Infectious Diseases
Lymph nodes
Lymphatic system
Medical Microbiology
Nucleotide sequence
Orf
Orf virus - genetics
Poxviridae
Poxviridae - genetics
RNA polymerase
Sheep
Skin
Virology
Viruses
Young Adult
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Description
Summary:Human orf disease (called ecthyma contagiosum or contagious/infectious pustular dermatitis in animals) was confirmed on the fingers of both hands of a 24-year-old female, after feeding diseased lambs with a nursing bottle in April 2023. In addition to skin symptoms, she had low-grade fever (37.6°C) and swollen lymph nodes in both axilla. The presence of orf virus (genus Parapoxvirus , family Poxviridae ) was confirmed, and this strain, Baja/2023/HUN (OR372161-OR372163), was found to have > 98% nucleotide sequence identity to sheep-origin orf viruses in four tested genome regions (ORF011/B2L, ORF019, ORF020/VIR, and ORF056). This is the first report of a human case of infection with the neglected zoonotic orf virus in Hungary.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-024-06002-w