Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV

Here, we provide the first regional analysis of intact and defective HIV reservoirs within the brain. Brain tissue from both viremic and virally suppressed people with HIV (PWH) harbored HIV pol DNA in all regions tested, with lower levels present in basal ganglia and cerebellum relative to frontal...

Full description

Saved in:
Bibliographic Details
Published in:Annals of neurology 2023-10, Vol.94 (4), p.798-802
Main Authors: Angelovich, Thomas A, Cochrane, Catherine R, Zhou, Jingling, Tumpach, Carolin, Byrnes, Sarah J, Jamal Eddine, Janna, Waring, Emily, Busman-Sahay, Kathleen, Deleage, Claire, Jenkins, Trisha A, Hearps, Anna C, Turville, Stuart, Gorry, Paul R, Lewin, Sharon R, Brew, Bruce J, Estes, Jacob D, Roche, Michael, Churchill, Melissa J
Format: Article
Language:English
Subjects:
Antiretroviral agents
Antiretroviral therapy
Basal ganglia
Brain
CD4-Positive T-Lymphocytes
Cerebellum
DNA biosynthesis
Ganglia
HIV
HIV Infections - drug therapy
HIV-1 - genetics
Human immunodeficiency virus
Humans
Proviruses
Proviruses - genetics
Regional analysis
Regional planning
Substantia alba
Viral Load
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Here, we provide the first regional analysis of intact and defective HIV reservoirs within the brain. Brain tissue from both viremic and virally suppressed people with HIV (PWH) harbored HIV pol DNA in all regions tested, with lower levels present in basal ganglia and cerebellum relative to frontal white matter. Intact proviruses were primarily found in the frontal white matter but also detected in other brain regions of PWH, demonstrating frontal white matter as a major brain reservoir of intact, potentially replication competent HIV DNA that persists despite antiretroviral therapy. ANN NEUROL 2023;94:798-802.
ISSN:0364-5134
1531-8249
1531-8249
DOI:10.1002/ana.26750