Placental transfer dynamics and durability of maternal COVID-19 vaccine-induced antibodies in infants

Completion of a COVID-19 vaccination series during pregnancy effectively reduces COVID-19 hospitalization among infants less than 6 months of age. The dynamics of transplacental transfer of maternal vaccine-induced antibodies, and their persistence in infants at 2, 6, 9, and 12 months, have implicat...

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Published in:iScience 2024-03, Vol.27 (3), p.109273, Article 109273
Main Authors: Lopez, Paola A., Nziza, Nadège, Chen, Tina, Shook, Lydia L., Burns, Madeleine D., Demidkin, Stepan, Jasset, Olyvia, Akinwunmi, Babatunde, Yonker, Lael M., Gray, Kathryn J., Elovitz, Michal A., Lauffenburger, Douglas A., Julg, Boris D., Edlow, Andrea G.
Format: Article
Language:English
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Health sciences
Immunology
Microbiology
Pediatrics
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Summary:Completion of a COVID-19 vaccination series during pregnancy effectively reduces COVID-19 hospitalization among infants less than 6 months of age. The dynamics of transplacental transfer of maternal vaccine-induced antibodies, and their persistence in infants at 2, 6, 9, and 12 months, have implications for new vaccine development and optimal timing of vaccine administration in pregnancy. We evaluated anti-COVID antibody IgG subclass, Fc-receptor binding profile, and activity against wild-type Spike and RBD plus five variants of concern (VOCs) in 153 serum samples from 100 infants. Maternal IgG1 and IgG3 responses persisted in 2- and 6-month infants to a greater extent than the other IgG subclasses, with high persistence of antibodies binding placental neonatal Fc-receptor and FcγR3A. Lowest persistence was observed against the Omicron RBD-specific region. Maternal vaccine timing, placental Fc-receptor binding capabilities, antibody subclass, fetal sex, and VOC all impact the persistence of antibodies in infants through 12 months of age. [Display omitted] •Maternal COVID-19 vaccine-induced antibodies persist in most infants through 6 months•IgG1 and IgG3 antibodies had the highest persistence in 2- and 6-month infants•Antibodies binding placental neonatal Fc-receptor and FcγR3A had high persistence•Timing of maternal vaccination and fetal sex influenced antibody persistence Classification Description: Health sciences; Pediatrics; Immunology; Microbiology
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2024.109273