Exploring the influence of circulating endocannabinoids and nucleus accumbens functional connectivity on anorexia nervosa severity

Anorexia nervosa (AN) is a severe psychiatric disorder characterized by a harmful persistence of self-imposed starvation resulting in significant weight loss. Research suggests that alterations in the nucleus accumbens (NAcc) and circulating endocannabinoids (eCBs), such as anandamide (AEA) and 2-ar...

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Published in:Molecular psychiatry 2023-11, Vol.28 (11), p.4793-4800
Main Authors: Miranda-Olivos, Romina, Baenas, Isabel, Steward, Trevor, Granero, Roser, Pastor, Antoni, Sánchez, Isabel, Juaneda-Seguí, Asier, del Pino-Gutiérrez, Amparo, Fernández-Formoso, José A., Vilarrasa, Nuria, Guerrero-Pérez, Fernando, Virgili, Nuria, López-Urdiales, Rafael, Jiménez-Murcia, Susana, de la Torre, Rafael, Soriano-Mas, Carles, Fernández-Aranda, Fernando
Format: Article
Language:English
Subjects:
2-Arachidonoylglycerol
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Anandamide
Anorexia
Behavioral Sciences
Biological Psychology
Body mass index
Cannabinoids
Eating disorders
Medicine
Medicine & Public Health
Neurosciences
Nucleus accumbens
Pharmacotherapy
Psychiatry
Supplementary motor area
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Summary:Anorexia nervosa (AN) is a severe psychiatric disorder characterized by a harmful persistence of self-imposed starvation resulting in significant weight loss. Research suggests that alterations in the nucleus accumbens (NAcc) and circulating endocannabinoids (eCBs), such as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), may contribute to increased severity and maladaptive behaviors in AN, warranting an examination of the interplay between central reward circuitry and eCBs. For this purpose, we assessed NAcc functional connectivity and circulating AEA and 2-AG concentrations in 18 individuals with AN and 18 healthy controls (HC) to test associations between circulating eCBs, NAcc functional connectivity, and AN severity, as defined by body mass index (BMI). Decreased connectivity was observed between the NAcc and the right insula (NAcc-insula; p FWE  
ISSN:1359-4184
1476-5578
DOI:10.1038/s41380-023-02253-2