Mitochondria: A Potential Rejuvenation Tool against Aging

Aging is a complex physiological process encompassing both physical and cognitive decline over time. This intricate process is governed by a multitude of hallmarks and pathways, which collectively contribute to the emergence of numerous age-related diseases. In response to the remarkable increase in...

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Bibliographic Details
Published in:Aging and disease 2024-04, Vol.15 (2), p.503-516
Main Authors: Phua, Qian Hua, Ng, Shi Yan, Soh, Boon-Seng
Format: Article
Language:English
Subjects:
Aging
Aging - physiology
Animals
Health aspects
Humans
Methods
Mitochondria
Mitochondria - metabolism
Physiological aspects
Proteomics
Rejuvenation
Rejuvenation - physiology
Review
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Summary:Aging is a complex physiological process encompassing both physical and cognitive decline over time. This intricate process is governed by a multitude of hallmarks and pathways, which collectively contribute to the emergence of numerous age-related diseases. In response to the remarkable increase in human life expectancy, there has been a substantial rise in research focusing on the development of anti-aging therapies and pharmacological interventions. Mitochondrial dysfunction, a critical factor in the aging process, significantly impacts overall cellular health. In this extensive review, we will explore the contemporary landscape of anti-aging strategies, placing particular emphasis on the promising potential of mitotherapy as a ground-breaking approach to counteract the aging process. Moreover, we will investigate the successful application of mitochondrial transplantation in both animal models and clinical trials, emphasizing its translational potential. Finally, we will discuss the inherent challenges and future possibilities of mitotherapy within the realm of aging research and intervention.
ISSN:2152-5250
2152-5250
DOI:10.14336/AD.2023.0712