Oscillatory Waveform Shape and Temporal Spike Correlations Differ across Bat Frontal and Auditory Cortex

Neural oscillations are associated with diverse computations in the mammalian brain. The waveform shape of oscillatory activity measured in the cortex relates to local physiology and can be informative about aberrant or dynamically changing states. However, how waveform shape differs across distant...

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Bibliographic Details
Published in:The Journal of neuroscience 2024-03, Vol.44 (10), p.e1236232023
Main Authors: García-Rosales, Francisco, Schaworonkow, Natalie, Hechavarria, Julio C
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
Auditory Cortex - physiology
Brain
Carollia perspicillata
Chiroptera
Correlation
Cortex (auditory)
Cortex (frontal)
Cortex (temporal)
Frequency ranges
Frontal Lobe
Hearing
Male
Oscillations
Waveforms
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Summary:Neural oscillations are associated with diverse computations in the mammalian brain. The waveform shape of oscillatory activity measured in the cortex relates to local physiology and can be informative about aberrant or dynamically changing states. However, how waveform shape differs across distant yet functionally and anatomically related cortical regions is largely unknown. In this study, we capitalize on simultaneous recordings of local field potentials (LFPs) in the auditory and frontal cortices of awake, male bats to examine, on a cycle-by-cycle basis, waveform shape differences across cortical regions. We find that waveform shape differs markedly in the fronto-auditory circuit even for temporally correlated rhythmic activity in comparable frequency ranges (i.e., in the delta and gamma bands) during spontaneous activity. In addition, we report consistent differences between areas in the variability of waveform shape across individual cycles. A conceptual model predicts higher spike-spike and spike-LFP correlations in regions with more asymmetric shapes, a phenomenon that was observed in the data: spike-spike and spike-LFP correlations were higher in the frontal cortex. The model suggests a relationship between waveform shape differences and differences in spike correlations across cortical areas. Altogether, these results indicate that oscillatory activity in the frontal and auditory cortex possesses distinct dynamics related to the anatomical and functional diversity of the fronto-auditory circuit.
ISSN:0270-6474
1529-2401
1529-2401
DOI:10.1523/JNEUROSCI.1236-23.2023